Evidence map›Paper›PMID 25733977›Full record

ArticleJournal of oncology2015

Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma.

Jun Osugi, Yuka Kimura, Yuki Owada, Takuya Inoue, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Satoshi Muto, Naoyuki Okabe, Yuki Matsumura and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Hypoxia A Typical Target in Human Lung Cancer Therapy.Current protein & peptide science · 2024
    Review
  7. Article
  8. Article
  9. Hypoxia-Induced Non-Coding RNAs Controlling Cell Viability in Cancer.International journal of molecular sciences · 2021
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. The role of miRNAs in the pheochromocytomas.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Jun OsugiDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Yuka KimuraDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Yuki OwadaDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Takuya InoueDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Yuzuru WatanabeDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Takumi YamauraDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Mitsuro FukuharaDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Satoshi MutoDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Naoyuki OkabeDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Yuki MatsumuraDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Takeo HasegawaDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Athushi YonechiDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Mika HoshinoDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Mitsunori HiguchiDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Yutaka ShioDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Hiroyuki SuzukiDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Mitsukazu GotohDepartment of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Fukushima Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective. The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC). Methods. We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University from 2004 to 2007, by using quantitative RT-PCR. The relationship between miR-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed. Results. miR-210 expression showed an inverse correlation with disease-free and overall survival in patients with NSCLC. Significant correlations were found between miR-210 expression and lymph node metastasis, late disease stages, and poor prognosis in patients with adenocarcinoma. Multivariate Cox analysis indicated that miR-210 expression was an independent prognostic factor for disease-free survival in patients with adenocarcinoma. Conclusions. We showed that miR-210 may be a prognostic biomarker for patients with NSCLC, especially for those with lung adenocarcinoma.

Identifiers

PMID25733977
PMCPMC4334982
OpenAlexW2056294995

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.