ArticleRisk management and healthcare policy2015
Necrotizing fasciitis: risk factors of mortality.
Article in Risk management and healthcare policy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Necrotising Fasciitis in Patients With Diabetes: A Systematic Review of Mortality-Associated Clinical Factors.International wound journal · 2026Pooled it
- Multifocal necrotizing fasciitis: what makes it different? A German trauma center experience.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Predicting limb amputation in trauma-related necrotizing fasciitis of the extremities: insights from a 10-year cohort.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Antibiotic Selection and Outcomes in Patients With Monomicrobial and PolymicrobialThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026Article
- Article
- Beyond the Break: Radiologic Diagnosis and Outcomes of Necrotizing Fasciitis Complicating Orthopedic Fractures.Cureus · 2025Review
- Predictors of clinical outcomes in necrotizing fasciitis: a ten year study.International orthopaedics · 2025Article
- Necrotizing Fasciitis Treatment With Chlorine Dioxide: A Case Report in an Immunocompromised Patient.Cureus · 2025Article
- Infection risk and management in patients with cirrhosis: A critical overview.World journal of hepatology · 2025Article
- Impact of liver cirrhosis on morbidity and mortality of patients admitted to the hospital with necrotizing fasciitis.World journal of hepatology · 2025Article
- Is overweight a predictor for a more severe course of disease in cases of necrotizing fasciitis?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Necrotizing fasciitis: treatment concepts & clinical outcomes - an institutional experience.BMC surgery · 2024Observational
- Management Outcome and Associated Factors of Necrotizing Soft Tissue Infections in an Ethiopian Tertiary Care Hospital: A-Five-Year Review.Ethiopian journal of health sciences · 2024Article
- Man with a swollen neck.Journal of the American College of Emergency Physicians open · 2024Article
- Retroperitoneal necrotizing fasciitis mimicking perforated appendicitis: A case report.International journal of surgery case reports · 2024Article
- [Neutrophil-lymphocyte ratio as predictor of mortality in patients with necrotizing fasciitis].Revista medica del Instituto Mexicano del Seguro Social · 2024Observational
- [62/m-Unclear soft tissue infection of the left thorax with rapid progression and subsequent sepsis : Preparation for the medical specialist examination: part 48].Chirurgie (Heidelberg, Germany) · 2023Article
- Hyperbaric oxygen treatment in the management of necrotising soft-tissue infections: results from a Danish nationwide registry study.BMJ open · 2023Article
- Sequential Organ Failure Assessment score in predicting the prognosis of necrotising fasciitis: a prospective study.Singapore medical journal · 2023Article
- Clinical Characteristics and Histopathology in Suspected Necrotizing Soft Tissue Infections.Open forum infectious diseases · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNecrotizing fasciitis (NF) is a serious infection of skin and soft tissues that rapidly progresses along the deep fascia. It becomes a fatal soft tissue infection with high mortality rate if treatment is delayed. Early diagnosis for emergency surgical debridement and broad-spectrum antibiotic therapy were the optimal treatments to reduce the mortality rate of NF.
objectiveThe aim of this study was to identify risk factors that increased the mortality rate in patients with NF under routine clinical practices.
methodsA retrospective cohort study was performed at three general hospitals located in northern Thailand. All medical records of patients with surgically confirmed NF treated between January 2009 and December 2012 were reviewed. Clinical predictors for mortality were analyzed using multivariable risk regression analysis.
resultsOf a total of 1,504 patients with a diagnosis of NF, 19.3% (n=290) died in hospital and 80.7% (n=1,214) survived. From multivariable analysis, being female (risk ratio [RR] =1.37, 95% confidence interval [CI] =1.01-1.84); age >60 (RR=1.39, 95% CI =1.25-1.53); having chronic heart disease (RR=1.64, 95% CI=1.18-2.28), cirrhosis (RR =2.36, 95% CI=1.70-3.27), skin necrosis (RR =1.22, 95% CI=1.15-1.28), pulse rate >130/min (RR =2.26, 95% CI=1.79-2.85), systolic BP <90 mmHg (RR =2.05, 95% CI =1.44-2.91), and serum creatinine ≥1.6 mg/dL (RR=3.06, 95% CI=2.08-4.50) were risk factors for mortality.
conclusionPrognostic factors for mortality in NF patients included being female; age >60; or having chronic heart disease, cirrhosis, skin necrosis, pulse rate >130/min, systolic BP <90 mmHg, and serum creatinine ≥1.6 mg/dL. Thus, disease progression to mortality may occur in such patients presenting one of these risk factors. Further examination or close monitoring for systemic involvement may be advantageous to reduce morbidity and mortality.
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