ArticleProceedings of the National Academy of Sciences of the United States of America2015
Climate change and pollution speed declines in zebrafish populations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 115 citations in OpenAlex.
- Article
- A Double Challenge for Fish: The Combined Stress of Warming and Pharmaceuticals in Aquatic Systems.Journal of xenobiotics · 2025Review
- Alternative Splicing and Gene Expression Variation Underlie Population and Life History Differences in an Amphibian.Ecology and evolution · 2025Article
- Consequences of Cancer on ZebrafishEcology and evolution · 2025Article
- Special Issue: Molecular Advance on Reproduction and Fertility of Aquatic Animals.International journal of molecular sciences · 2024Article
- Characterization of the reproductive strategy of invasive Round Goby (Ecology and evolution · 2024Article
- Endocrine-Disruptive Effects of Adenylate Cyclase Activator Forskolin: In Vitro and In Vivo Evidence.Toxics · 2024Article
- The regulation of endocrine-disrupting chemicals to minimize their impact on health.Nature reviews. Endocrinology · 2023Review
- Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals.Environmental science & technology · 2023Review
- Development of epigenetic biomarkers for the identification of sex and thermal stress in fish using DNA methylation analysis and machine learning procedures.Molecular ecology resources · 2023Article
- Environmentally-induced sex reversal in fish with chromosomal vs. polygenic sex determination.Environmental research · 2022Article
- Frontiers in quantifying wildlife behavioural responses to chemical pollution.Biological reviews of the Cambridge Philosophical Society · 2022Review
- A Multidimensional Matrix Model for Predicting the Effects of Male-Biased Sex Ratios on Fish Populations.Environmental toxicology and chemistry · 2022Article
- Sexual determination in zebrafish.Cellular and molecular life sciences : CMLS · 2021Review
- Shedding new light on early sex determination in zebrafish.Archives of toxicology · 2020Article
- Gonad metabolomics and blood biochemical analysis reveal differences associated with testicular oocytes in wild largemouth bass (Micropterus salmoides).Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2020Article
- Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases.Frontiers in public health · 2020Review
- Efficient phenotypic sex classification of zebrafish using machine learning methods.Ecology and evolution · 2019Article
- Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio).BMC genomics · 2019Article
- Phenotypic plasticity induced using high ambient temperature during embryogenesis in domesticated zebrafish, Danio rerio.Reproduction in domestic animals = Zuchthygiene · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Endocrine disrupting chemicals (EDCs) are potent environmental contaminants, and their effects on wildlife populations could be exacerbated by climate change, especially in species with environmental sex determination. Endangered species may be particularly at risk because inbreeding depression and stochastic fluctuations in male and female numbers are often observed in the small populations that typify these taxa. Here, we assessed the interactive effects of water temperature and EDC exposure on sexual development and population viability of inbred and outbred zebrafish (Danio rerio). Water temperatures adopted were 28 °C (current ambient mean spawning temperature) and 33 °C (projected for the year 2100). The EDC selected was clotrimazole (at 2 μg/L and 10 μg/L), a widely used antifungal chemical that inhibits a key steroidogenic enzyme [cytochrome P450(CYP19) aromatase] required for estrogen synthesis in vertebrates. Elevated water temperature and clotrimazole exposure independently induced male-skewed sex ratios, and the effects of clotrimazole were greater at the higher temperature. Male sex ratio skews also occurred for the lower clotrimazole exposure concentration at the higher water temperature in inbred fish but not in outbred fish. Population viability analysis showed that population growth rates declined sharply in response to male skews and declines for inbred populations occurred at lower male skews than for outbred populations. These results indicate that elevated temperature associated with climate change can amplify the effects of EDCs and these effects are likely to be most acute in small, inbred populations exhibiting environmental sex determination and/or differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.