Evidence map›Paper›PMID 25733562›Full record

ArticleInternational health2015

Adult vector control, mosquito ecology and malaria transmission.

Oliver J Brady, H Charles J Godfray, Andrew J Tatem, Peter W Gething, Justin M Cohen, F Ellis McKenzie, T Alex Perkins, Robert C Reiner, Lucy S Tusting, Thomas W Scott and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. [Re-transmission risk prediction of imported Chikungunya fever in Guangdong Province using the SEIR-SEI model].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  2. Article
  3. Article
  4. Climate Change and Malaria: A Call for Robust Analytics.medRxiv : the preprint server for health sciences · 2025
    Article
  5. Article
  6. Article
  7. Spatial dynamics of malaria transmission.PLoS computational biology · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. A New Test of a Theory about Old Mosquitoes.Trends in parasitology · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Oliver J BradySpatial Ecology and Epidemiology Group, Department of Zoology, Oxford University, Oxford, UK oliver.brady@zoo.ox.ac.uk.
H Charles J GodfrayDepartment of Zoology, University of Oxford, UK.
Andrew J TatemDepartment of Geography and Environment, University of Southampton, Southampton, UK Fogarty International Center, NIH, Bethesda, MD, USA Flowminder Foundation, Stockholm, Sweden.
Peter W GethingSpatial Ecology and Epidemiology Group, Department of Zoology, Oxford University, Oxford, UK.
Justin M CohenClinton Health Access Initiative, Boston, MA, USA.
F Ellis McKenzieFogarty International Center, NIH, Bethesda, MD, USA.
T Alex PerkinsFogarty International Center, NIH, Bethesda, MD, USA Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA Department of Entomology and Nematology, University of California, Davis, CA, USA.
Robert C ReinerFogarty International Center, NIH, Bethesda, MD, USA Department of Entomology and Nematology, University of California, Davis, CA, USA Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN, USA.
Lucy S TustingDepartment of Disease Control, London School of Hygiene & Tropical Medicine, London, UK.
Thomas W ScottFogarty International Center, NIH, Bethesda, MD, USA Department of Entomology and Nematology, University of California, Davis, CA, USA.
Steven W LindsaySchool of Biological Sciences, Durham University, Durham, UK.
Simon I HaySpatial Ecology and Epidemiology Group, Department of Zoology, Oxford University, Oxford, UK Fogarty International Center, NIH, Bethesda, MD, USA.
David L SmithSpatial Ecology and Epidemiology Group, Department of Zoology, Oxford University, Oxford, UK Fogarty International Center, NIH, Bethesda, MD, USA Sanaria Institute for Global Health and Tropical Medicine, Rockville, MD, USA.

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2010 to 2026
$29.3M
Biotechnology and Biological Sciences Research CouncilNIAID NIH HHS U19 AI089674NIAID NIH HHS U19AI089674Wellcome Trust 095066
6 · The paper itself

Abstract

backgroundStandard advice regarding vector control is to prefer interventions that reduce the lifespan of adult mosquitoes. The basis for this advice is a decades-old sensitivity analysis of 'vectorial capacity', a concept relevant for most malaria transmission models and based solely on adult mosquito population dynamics. Recent advances in micro-simulation models offer an opportunity to expand the theory of vectorial capacity to include both adult and juvenile mosquito stages in the model.

methodsIn this study we revisit arguments about transmission and its sensitivity to mosquito bionomic parameters using an elasticity analysis of developed formulations of vectorial capacity.

resultsWe show that reducing adult survival has effects on both adult and juvenile population size, which are significant for transmission and not accounted for in traditional formulations of vectorial capacity. The elasticity of these effects is dependent on various mosquito population parameters, which we explore. Overall, control is most sensitive to methods that affect adult mosquito mortality rates, followed by blood feeding frequency, human blood feeding habit, and lastly, to adult mosquito population density.

conclusionsThese results emphasise more strongly than ever the sensitivity of transmission to adult mosquito mortality, but also suggest the high potential of combinations of interventions including larval source management. This must be done with caution, however, as policy requires a more careful consideration of costs, operational difficulties and policy goals in relation to baseline transmission.

Indexed as

CulicidaeInsect VectorsLife Cycle StagesMosquito ControlPopulation DynamicsAdultAnimalsAnophelesEcologyHealth PolicyHumansLarvaMalariaModels, BiologicalPopulation DensityLarval controlMalaria control policyMicro-simulation modelsPlasmodium falciparumPlasmodium vivaxVectorial capacity

Identifiers

PMID25733562
PMCPMC4357799

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.