Evidence map›Paper›PMID 25733525›Full record

ArticleJournal of the American Society of Nephrology : JASN2015

Cause of Death in Patients with Reduced Kidney Function.

Stephanie Thompson, Matthew James, Natasha Wiebe, Brenda Hemmelgarn, Braden Manns, Scott Klarenbach, Marcello Tonelli, Alberta Kidney Disease Network

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 400 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
400citing papers in PubMed, 10 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

400 citing papers in PubMed, 10 syntheses or guidelines pooled it, 637 citations in OpenAlex.

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  16. The Intersection of Heart Failure with Preserved Ejection Fraction and CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
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  18. Article
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340 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Stephanie ThompsonDivision of Nephrology, University of Alberta, Edmonton, Alberta, Canada; and.
Matthew JamesDivision of Nephrology, University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canada.
Natasha WiebeDivision of Nephrology, University of Alberta, Edmonton, Alberta, Canada; and.
Brenda HemmelgarnDivision of Nephrology, University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canada.
Braden MannsDivision of Nephrology, University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canada.
Scott KlarenbachDivision of Nephrology, University of Alberta, Edmonton, Alberta, Canada; and.
Marcello TonelliDivision of Nephrology, University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canada mtonelli@ualberta.ca.
Alberta Kidney Disease Network
Foothills Medical Centre · CAUniversity of Alberta · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Information on common causes of death in people with CKD is limited. We hypothesized that, as eGFR declines, cardiovascular mortality and mortality from infection account for increasing proportions of deaths. We calculated eGFR using the CKD Epidemiology Collaboration equation for residents of Alberta, Canada who died between 2002 and 2009. We used multinomial logistic regression to estimate unadjusted and age- and sex-adjusted differences in the proportions of deaths from each cause according to the severity of CKD. Cause of death was classified as cardiovascular, infection, cancer, other, or not reported using International Classification of Diseases codes. Among 81,064 deaths, the most common cause was cancer (31.9%) followed by cardiovascular disease (30.2%). The most common cause of death for those with eGFR≥60 ml/min per 1.73 m(2) and no proteinuria was cancer (38.1%); the most common cause of death for those with eGFR<60 ml/min per 1.73 m(2) was cardiovascular disease. The unadjusted proportion of patients who died from cardiovascular disease increased as eGFR decreased (20.7%, 36.8%, 41.2%, and 43.7% of patients with eGFR≥60 [with proteinuria], 45-59.9, 30-44.9, and 15-29.9 ml/min per 1.73 m(2), respectively). The proportions of deaths from heart failure and valvular disease specifically increased with declining eGFR along with the proportions of deaths from infectious and other causes, whereas the proportion of deaths from cancer decreased. In conclusion, we found an inverse association between eGFR and specific causes of death, including specific types of cardiovascular disease, infection, and other causes, in this cohort.

Indexed as

AdolescentAdultCardiovascular DiseasesCause of DeathFemaleHumansMaleMiddle AgedRenal Insufficiency, ChronicYoung Adultcardiovascular diseaseCKDepidemiology and outcomesGFRmortality

Identifiers

PMID25733525
PMCPMC4587695
OpenAlexW2096537254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.