ArticleThe Journal of nutrition2015
Multivitamin-mineral use is associated with reduced risk of cardiovascular disease mortality among women in the United States.
Article in The Journal of nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evaluating agreement between individual nutrition randomised controlled trials and cohort studies - a meta-epidemiological study.BMC medicine · 2025Pooled it
- Homocysteine-lowering interventions for preventing cardiovascular events.The Cochrane database of systematic reviews · 2017Pooled it
- Multivitamins in the prevention of cancer and cardiovascular disease: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial.The American journal of clinical nutrition · 2022Trial
- Trial
- Multivitamin Use and the Risk of Cardiovascular Disease in Men.The Journal of nutrition · 2016Trial
- Effects of Cocoa Extract and Multivitamin Supplementation on Venous Thromboembolism in the COSMOS Trial.Thrombosis and haemostasis · 2026Article
- Multivitamin Use and Mortality Risk in 3 Prospective US Cohorts.JAMA network open · 2024Article
- Dietary supplements increase the risk of excessive micronutrient intakes in Danish children.European journal of nutrition · 2023Article
- Multivitamin/mineral supplementation and the risk of cardiovascular disease: a large prospective study using UK Biobank data.European journal of nutrition · 2022Article
- Design and baseline characteristics of participants in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).Contemporary clinical trials · 2022Article
- Effects of vitamin supplements on clinical cardiovascular outcomes: Time to move on! - A comprehensive review.Clinical nutrition ESPEN · 2021Review
- Comparison of 4 Methods to Assess the Prevalence of Use and Estimates of Nutrient Intakes from Dietary Supplements among US Adults.The Journal of nutrition · 2020Article
- Predictors of toxic metal exposures among US women of reproductive age.Journal of exposure science & environmental epidemiology · 2019Article
- The balance between food and dietary supplements in the general population.The Proceedings of the Nutrition Society · 2019Article
- Dietary Supplement Use Differs by Socioeconomic and Health-Related Characteristics among U.S. Adults, NHANES 2011⁻2014.Nutrients · 2018Article
- Federal Monitoring of Dietary Supplement Use in the Resident, Civilian, Noninstitutionalized US Population, National Health and Nutrition Examination SurveyThe Journal of nutrition · 2018Review
- Evidence of Drug-Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update.Pharmaceutics · 2018Review
- The Evolving Role of Multivitamin/Multimineral Supplement Use among Adults in the Age of Personalized Nutrition.Nutrients · 2018Review
- Vitamin panacea: Is advertising fueling demand for products with uncertain scientific benefit?Journal of health economics · 2017Article
- Dietary supplement use in the older population of Iceland and association with mortality.The British journal of nutrition · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultivitamin-mineral (MVM) products are the most commonly used supplements in the United States, followed by multivitamin (MV) products. Two randomized clinical trials (RCTs) did not show an effect of MVMs or MVs on cardiovascular disease (CVD) mortality; however, no clinical trial data are available for women with MVM supplement use and CVD mortality.
objectiveThe objective of this research was to examine the association between MVM and MV use and CVD-specific mortality among US adults without CVD.
methodsA nationally representative sample of adults from the restricted data NHANES III (1988-1994; n = 8678; age ≥40 y) were matched with mortality data reported by the National Death Index through 2011 to examine associations between MVM and MV use and CVD mortality by using Cox proportional hazards models, adjusting for multiple potential confounders.
resultsWe observed no significant association between CVD mortality and users of MVMs or MVs compared with nonusers; however, when users were classified by the reported length of time products were used, a significant association was found with MVM use of >3 y compared with nonusers (HR: 0.65; 95% CI: 0.49, 0.85). This finding was largely driven by the significant association among women (HR: 0.56; 95% CI: 0.37, 0.85) but not men (HR: 0.79; 95% CI: 0.44, 1.42). No significant association was observed for MV products and CVD mortality in fully adjusted models.
conclusionsIn this nationally representative data set with detailed information on supplement use and CVD mortality data ∼20 y later, we found an association between MVM use of >3 y and reduced CVD mortality risk for women when models controlled for age, race, education, body mass index, alcohol, aspirin use, serum lipids, blood pressure, and blood glucose/glycated hemoglobin. Our results are consistent with the 1 available RCT in men, indicating no relation with MVM use and CVD mortality.
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