Evidence map›Paper›PMID 25733147›Full record

ReviewCurrent topics in developmental biology2015

Cell adhesion in epidermal development and barrier formation.

Kaelyn D Sumigray, Terry Lechler

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 108 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Mechanisms of cortical microtubule organization in epidermal keratinocytes.Cellular and molecular life sciences : CMLS · 2025
    Article
  9. Deciphering the molecular drivers for cashmere/pashmina fiber production in goats: a comprehensive review.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  10. Article
  11. The intersection ofFrontiers in cellular and infection microbiology · 2025
    Review
  12. Review
  13. Frontiers in pharmacology · 2025
    Article
  14. Article
  15. Desmosomes at a glance.Journal of cell science · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kaelyn D SumigrayDepartment of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA.
Terry LechlerDepartment of Dermatology, Duke University Medical Center, Durham, North Carolina, USA; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: terry.lechler@duke.edu.
Duke Medical Center · USDuke University Hospital · US

Funding

Role of Cell Adhesion and the Cytoskeleton in Epidermal IntegrityR01AR055926 · NIAMS · DUKE UNIVERSITY · PI LECHLER, TERRY H · 2009 to 2019
$3.7M
Differentiation Induced Changes in Centrosomes and Microtubule OrganizationR01GM111336 · NIGMS · DUKE UNIVERSITY · PI LECHLER, TERRY H · 2014 to 2017
$1.2M
NIAMS NIH HHS R01 AR055926NIGMS NIH HHS R01 GM111336
6 · The paper itself

Abstract

Cell-cell adhesions are necessary for structural integrity and barrier formation of the epidermis. Here, we discuss insights from genetic and cell biological studies into the roles of individual cell-cell junctions and their composite proteins in regulating epidermal development and function. In addition to individual adhesive functions, we will discuss emerging ideas on mechanosensation/transduction of junctions in the epidermis, noncanonical roles for adhesion proteins, and crosstalk/interdependencies between the junctional systems. These studies have revealed that cell adhesion proteins are connected to many aspects of tissue physiology including growth control, differentiation, and inflammation.

Indexed as

Epidermal CellsAdherens JunctionsAnimalsCell AdhesionCell Adhesion MoleculesCell DifferentiationEpidermisHumansSignal TransductionCell Adhesion MoleculesAdherens junctionAdhesionBarrierCytoskeletonDesmosomeEpidermisSkinTight junction

Identifiers

PMID25733147
PMCPMC4737682
OpenAlexW195691297

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.