ArticleBrain, behavior, and immunity2015
Sleep disturbance and longitudinal risk of inflammation: Moderating influences of social integration and social isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) study.
Article in Brain, behavior, and immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Sleep disorders in cystic fibrosis: A systematic review and meta-analysis.Sleep medicine reviews · 2020Pooled it
- Sleep fragmentation and heightened inflammation: A latent profile subtype predicting nine-year major depressive disorder severity in the MIDUS study.Brain, behavior, & immunity - health · 2026Article
- Insomnia and Inflammation Conspire to Heighten Depression Risk: Implications for Treatment and Prevention of Mood Disorders.Biological psychiatry · 2025Review
- Does Loneliness Hurt? Effect of Loneliness on Inflammator Biomarkers, Appetite Hormone Regulation, and Cognitive Function Among Typically Developing Adolescents.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2025Article
- Linking Social Cohesion to Biological Markers of Aging: Evidence From the National Health and Aging Trends Study.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- Association of sleep duration with hypertension in young and middle-aged adults: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2025Review
- Letter to the Editor Regarding: "Association between Metabolic Score for Insulin Resistance (METS-IR) and Risk of Obstructive Sleep Apnea: Analysis of NHANES Database and a Chinese Cohort" [Letter].Nature and science of sleep · 2025Article
- The Role of Essential Oils on Sleep Quality and Other Sleep-related Issues: Evidence from Clinical Trials.Mini reviews in medicinal chemistry · 2025Review
- The role of Klotho and sirtuins in sleep-related cardiovascular diseases: a review study.npj aging · 2024Review
- Associations of 24-hour movement behaviors with depressive symptoms in rural-dwelling older adults: a compositional data analysis.Aging clinical and experimental research · 2024Article
- Stress and Sleep Duration in Immune and Neuroendocrine Patterning. An Analytical Triangulation in ELSA.medRxiv : the preprint server for health sciences · 2024Article
- Article
- Network Pharmacology Analysis of the Potential Pharmacological Mechanism of a Sleep Cocktail.Biomolecules · 2024Article
- The Influence of Social Dynamics on Biological Aging and the Health of Historically Marginalized Populations: A Biopsychosocial Model for Health Disparities.International journal of environmental research and public health · 2024Review
- Upsetting the Balance: How Modifiable Risk Factors Contribute to the Progression of Alzheimer's Disease.Biomolecules · 2024Review
- Unique and cumulative effects of different subtypes of sleep problems on burnout among Chinese nurses.Frontiers in psychology · 2024Article
- A narrative review of mechanisms linking romantic relationship experiences to sleep quality.Sleep advances : a journal of the Sleep Research Society · 2024Review
- Sleep disturbance, but not depression severity, is associated with inflammation in children and adolescents.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis.Nature reviews. Rheumatology · 2023Review
- Inflammatory hypotheses of sleep disturbance - depression link: Update and research agenda.Brain, behavior, & immunity - health · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Both sleep disturbance and social isolation increase the risk for morbidity and mortality. Systemic inflammation is suspected as a potential mechanism of these associations. However, the complex relationships between sleep disturbance, social isolation, and inflammation have not been examined in a population-based longitudinal study. This study examined the longitudinal association between sleep disturbance and systemic inflammation, and the moderating effects of social isolation on this association. The CARDIA study is a population-based longitudinal study conducted in four US cities. Sleep disturbance - i.e., insomnia complaints and short sleep duration - was assessed in 2962 African-American and White adults at baseline (2000-2001, ages 33-45years). Circulating C-reactive protein (CRP) was measured at baseline and follow-up (2005-2006). Interleukin-6 (IL-6) and subjective and objective social isolation (i.e., feelings of social isolation and social network size) were measured at follow-up. Sleep disturbance was a significant predictor of inflammation five years later after full adjustment for covariates (adjusted betas: 0.048, P=0.012 for CRP; 0.047, P=0.017 for IL-6). Further adjustment for baseline CRP revealed that sleep disturbance also impacted the longitudinal change in CRP levels over five years (adjusted beta: 0.044, P=0.013). Subjective social isolation was a significant moderator of this association between sleep disturbance and CRP (adjusted beta 0.131, P=0.002). Sleep disturbance was associated with heightened systemic inflammation in a general population over a five-year follow-up, and this association was significantly stronger in those who reported feelings of social isolation. Clinical interventions targeting sleep disturbances may be a potential avenue for reducing inflammation, particularly in individuals who feel socially isolated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.