ArticleMagnetic resonance in medicine2016
Steady pulsed imaging and labeling scheme for noninvasive perfusion imaging.
Article in Magnetic resonance in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Rapid Tissue-CSF Water Exchange in the Human Brain Revealed by Magnetization Transfer Indirect Spin Labeling.Magnetic resonance in medicine · 2026Article
- Whole-brain perfusion mapping in mice by dynamic BOLD MRI with transient hypoxia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Quantitative cerebrovascular reactivity MRI in mice using acetazolamide challenge.Magnetic resonance in medicine · 2022Article
- Numerical approximation to the general kinetic model for ASL quantification.Magnetic resonance in medicine · 2020Article
- Improved velocity-selective-inversion arterial spin labeling for cerebral blood flow mapping with 3D acquisition.Magnetic resonance in medicine · 2020Article
- Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study.Frontiers in neurology · 2020Article
- Optimization of phase-contrast MRI for the estimation of global cerebral blood flow of mice at 11.7T.Magnetic resonance in medicine · 2019Article
- CEST, ASL, and magnetization transfer contrast: How similar pulse sequences detect different phenomena.Magnetic resonance in medicine · 2018Review
- Sensitivity of Multiphase Pseudocontinuous Arterial Spin Labelling (MP pCASL) Magnetic Resonance Imaging for Measuring Brain and Tumour Blood Flow in Mice.Contrast media & molecular imaging · 2018Article
- An immunocompetent mouse model of human glioblastoma.Oncotarget · 2017Article
- Velocity-selective-inversion prepared arterial spin labeling.Magnetic resonance in medicine · 2016Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
purposeA steady pulsed imaging and labeling (SPIL) scheme is proposed to obtain high-resolution multislice perfusion images of mice brain using standard preclinical MRI equipment. THEORY AND
methodsThe SPIL scheme repeats a pulsed arterial spin labeling (PASL) module together with a short mixing time to extend the temporal duration of the generated PASL bolus to the total experimental time. Multislice image acquisition takes place during the mixing times. The mixing time is also used for magnetization recovery following image acquisition. The new scheme is able to yield multislice perfusion images rapidly. The perfusion kinetic curve can be measured by a multipulsed imaging and labeling (MPIL) scheme, i.e., acquiring single-slice ASL signals before reaching steady-state in the SPIL sequence.
resultsWhen applying the SPIL method to normal mice, and to mice with unilateral ischemia, high-resolution multislice (five slices) CBF images could be obtained in 8 min. Perfusion data from ischemic mice showed clear CBF reductions in ischemic regions. The SPIL method was also applied to postmortem mice, showing that the method is free from magnetization transfer confounds.
conclusionThe new SPIL scheme provides for robust measurement of CBF with multislice imaging capability in small animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.