ArticleCell reports2015
Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Hedgehog pathway, cell cycle, and primary cilium.Cell death discovery · 2025Review
- Article
- Regulatory mechanisms of cytoneme-based morphogen transport.Cellular and molecular life sciences : CMLS · 2022Review
- Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE.Frontiers in cell and developmental biology · 2022Article
- Structure, mechanism, and inhibition of Hedgehog acyltransferase.Molecular cell · 2021Article
- Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease.Open biology · 2021Review
- Hedgehog Signal and Genetic Disorders.Frontiers in genetics · 2019Review
- Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.Journal of neuro-oncology · 2018Article
- Article
- Taking the Occam's Razor Approach to Hedgehog Lipidation and Its Role in Development.Journal of developmental biology · 2018Review
- Article
- A fixation method to preserve cultured cell cytonemes facilitates mechanistic interrogation of morphogen transport.Development (Cambridge, England) · 2017Article
- RNA-seq reveals conservation of function among the yolk sacs of human, mouse, and chicken.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Hedgehog Proteins Consume Steroidal CYP17A1 Antagonists: Potential Therapeutic Significance in Advanced Prostate Cancer.ChemMedChem · 2016Article
- Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway.Scientific reports · 2016Article
- Sonic Hedgehog: a lipid speciated hormone?Oncotarget · 2015Article
- Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine.Current medicinal chemistry · 2015Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Hedgehog (HH) proteins are proteolytically processed into a biologically active form that is covalently modified by cholesterol and palmitate. However, most studies of HH biogenesis have characterized protein from cells in which HH is overexpressed. We purified Sonic Hedgehog (SHH) from cells expressing physiologically relevant levels and showed that it was more potent than SHH isolated from overexpressing cells. Furthermore, the SHH in our preparations was modified with a diverse spectrum of fatty acids on its amino termini, and this spectrum of fatty acids varied dramatically depending on the growth conditions of the cells. The fatty acid composition of SHH affected its trafficking to lipid rafts as well as its potency. Our results suggest that HH proteins exist as a family of diverse lipid-speciated proteins that might be altered in different physiological and pathological contexts in order to regulate distinct properties of HH proteins.
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Registered trials
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