Evidence map›Paper›PMID 25732801›Full record

ArticleJournal of the neurological sciences2015

High-resolution MRI vessel wall imaging in varicella zoster virus vasculopathy.

Esteban Cheng-Ching, Stephen Jones, Ferdinand K Hui, Shumei Man, Don Gilden, Adarsh Bhimraj, Ken Uchino

Abstract readCase Reports
In one paragraph

Article in Journal of the neurological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
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  3. MR Intracranial Vessel Wall Imaging: A Systematic Review.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020
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  10. Post-infectious central nervous system vasculitides in adults: an underdiagnosed and treatable disease part II. Neuroimaging of selected etiologies : Part II. Neuroimaging of selected etiologies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Esteban Cheng-ChingDepartment of Neuroradiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.
Stephen JonesDepartment of Neuroradiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.
Ferdinand K HuiCerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Shumei ManDepartment of Neurology, Wright State University, Dayton, OH, USA.
Don GildenDepartment of Neurology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Microbiology and Immunology, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address: don.gilden@ucdenver.edu.
Adarsh BhimrajDepartment of Infectious Diseases, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Ken UchinoCerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Cleveland Clinic · USThe Neurological Institute · USUniversity of Colorado Denver · USWright State University · US

Funding

VARICELLA ZOSTER VIRUS VASCULOPATHY: CHANGING CLINICAL PRACTICEP01AG032958 · NIA · UNIVERSITY OF COLORADO DENVER · PI COHRS, RANDALL J. · 2009 to 2023
$30.3M
NEUROBIOLOGY OF VARICELLA-ZOSTER VIRUSR01AG006127 · NIA · UNIVERSITY OF COLORADO DENVER · PI GILDEN, DONALD · 1987 to 2014
$4.2M
NEUROBIOLOGY OF VARICELLA ZOSTER VIRUSR37AG006127 · NIA · UNIVERSITY OF COLORADO DENVER · PI GILDEN, DONALD H · 1995 to 2004
$2.3M
NIA NIH HHS AG006127NIA NIH HHS AG032958NIA NIH HHS P01 AG032958NIA NIH HHS R01 AG006127NIA NIH HHS R37 AG006127
6 · The paper itself

Abstract

Contrast-enhanced vessel wall imaging high-resolution MRI (HRMR) has revealed vessel wall thickening and enhancement in multiple intracranial vasculopathies, including varicella zoster virus (VZV) vasculopathy. We retrospectively reviewed a database of patients with virologically-verified VZV vasculopathy, who underwent initial and follow-up HRMR between April 2011 and May 2014. Six patients were identified. Baseline demographic and clinical characteristics were collected, including stroke risk factors, history of VZV-related disorders, neurological presentation, course and antiviral treatment. Initial HRMR in patients with VZV vasculopathy demonstrated various patterns of stenosis, vessel wall thickening and enhancement, predominantly in terminal internal carotid artery segments and the M1 segment of the middle cerebral arteries. Follow-up HRMR showed improvement of stenosis, with reduced vessel wall thickening and enhancement at multiple times after treatment. HRMR has the potential to assist in diagnosis and treatment of VZV vasculopathy.

Indexed as

AdultAgedCarotid Artery DiseasesCerebral Arterial DiseasesFemaleHerpesvirus 3, HumanHerpes ZosterHumansMagnetic Resonance ImagingMaleMiddle AgedMiddle Cerebral ArteryRetrospective StudiesAngiographyHigh-resolutionMRITreatmentVaricella zoster virusVasculopathy

Identifiers

PMID25732801
PMCPMC4385445
OpenAlexW2085958391

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.