Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2015
Test-Retest Reliability and Stability of the Nicotine Metabolite Ratio Among Treatment-Seeking Smokers.
Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01314001 (Pharmacogenetics of Nicotine Addiction Treatment), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacogenetics of Nicotine Addiction Treatment (PNAT)
Who cites it
14 citing papers in PubMed.
- Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults.British journal of clinical pharmacology · 2019Trial
- Rate of nicotine metabolism on risk of myocardial infarction among people with HIV who smoke cigarettes.PloS one · 2026Article
- The use of biomarkers to guide precision treatment for tobacco use.Addiction neuroscience · 2023Article
- Examining racial differences in smoking outcomes among smokers enrolled in an intravenous nicotine infusion study.Addictive behaviors · 2023Article
- Resting-state electroencephalography theta predicts neurofeedback treatment 4-month follow-up response in nicotine addiction.General psychiatry · 2023Article
- Associations of biomarkers for exposure to tobacco smoke with lung cancer risk in Korea.Cancer biomarkers : section A of Disease markers · 2022Article
- Associations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Does the nicotine metabolite ratio moderate smoking cessation treatment outcomes in real-world settings? A prospective study.Addiction (Abingdon, England) · 2019Observational
- Preparing the Way: Exploiting Genomic Medicine to Stop Smoking.Trends in molecular medicine · 2018Review
- Characterising the nicotine metabolite ratio and its association with treatment choice: A cross sectional analysis of Stop Smoking Services in England.Scientific reports · 2017Article
- Precision medicine and pharmacogenetics: what does oncology have that addiction medicine does not?Addiction (Abingdon, England) · 2017Review
- Genome-Wide Association of the Laboratory-Based Nicotine Metabolite Ratio in Three Ancestries.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- Precision Medicine for Tobacco Dependence: Development and Validation of the Nicotine Metabolite Ratio.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Review
- Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate.Biological psychiatry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
introductionThe nicotine metabolite ratio (NMR), the ratio of 3-hydroxycotinine to cotinine, is a biomarker used in smoking cessation research, with several retrospective studies suggesting that NMR predicts treatment outcome. To be maximally useful in tailoring treatment, estimates of NMR should be stable over time. The present study is the first to examine the short-term test-retest reliability of NMR among treatment-seeking smokers.
methodsBlood NMR was assessed at two time points, approximately 2-3 weeks apart and prior to intervention, among 72 healthy adult smokers (49% female; 35% non-White) enrolled in a cessation trial (http://ClinicalTrials.gov ID: NCT01314001).
resultsMean NMR was stable from Time-1 to Time-2, with no significant change between assessments; test-retest reliability for NMR values was excellent (ICC[2,1] = 0.87). Test-retest reliability remained acceptable to high when NMR was categorized, as in recent clinical trials. Classification of participants as slow (quartile 1, NMR ≤ 0.24) or normal/fast NMR (quartiles 2-4, NMR ≥ 0.25) was consistent from Time-1 to Time-2 for 96% of participants (κ = 0.89). Though classification of participants into NMR quartiles was less consistent from Time-1 to Time-2 (67% agreement; weighted κ = 0.73), all reclassifications occurred between adjacent quartiles.
conclusionsOverall, these data support the use of a single NMR assessment for association studies with smoking phenotypes and in smokers seeking to quit, and they encourage large-scale efforts to determine optimal NMR cutpoints for tailoring treatment selection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.