ArticleJournal of experimental botany2015
A wheat ABC transporter contributes to both grain formation and mycotoxin tolerance.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 111 citations in OpenAlex.
- Functional validation of OsRPM1 as a positive regulator of bacterial blight resistance in rice via virus-induced gene silencing.Folia microbiologica · 2026Article
- Integrated genomic and transcriptomic analysis reveals candidate genes underlying herbicide resistance in Sorghum.BMC plant biology · 2026Article
- Uncovering the Genetic Basis of Grain Protein Content and Wet Gluten Content in Common Wheat (Plants (Basel, Switzerland) · 2026Article
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- Comparative Enzymatic and Gene Expression Responses in Wheat to DON- and NIV-ProducingBiology · 2025Article
- Identification of maize genes that condition early systemic infection of sugarcane mosaic virus through single-cell transcriptomics.Plant communications · 2025Article
- Comprehensive analysis of cinnamoyl-CoA reductase (CCR) gene family in wheat: implications for lignin biosynthesis and stress responses.BMC plant biology · 2025Article
- Comparative transcriptomes reveal insights into different host responses associated with Fusarium head blight resistance in wheat.BMC plant biology · 2025Article
- Horizontally acquired CSP genes contribute to wheat adaptation and improvement.Nature plants · 2025Article
- GWAS analysis of Fusarium head blight resistance in a Nordic-Baltic spring wheat panel.Frontiers in plant science · 2025Article
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- Transcriptomic analysis of two Chinese wheat landraces with contrasting Fusarium head blight resistance reveals miRNA-mediated defense mechanisms.Frontiers in plant science · 2025Article
- Molecular Investigations to Improve Fusarium Head Blight Resistance in Wheat: An Update Focusing on Multi-Omics Approaches.Plants (Basel, Switzerland) · 2024Review
- Trichothecenes and Fumonisins: Key Players inToxins · 2024Review
- Occurrence of Mycotoxins in Foods: Unraveling the Knowledge Gaps on Their Persistence in Food Production Systems.Foods (Basel, Switzerland) · 2023Review
- Comparative transcriptomic analysis of wheat cultivars differing in their resistance to Fusarium head blight infection during grain-filling stages reveals unique defense mechanisms at play.BMC plant biology · 2023Article
- Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-aBIOTECH · 2023Review
- Combined Transcriptome and Metabolome Analysis Reveals Adaptive Defense Responses to DON Induction in Potato.International journal of molecular sciences · 2023Article
- The HMA2 Gene Expression in Leaves of Introgressive Wheat Lines under Zn Optimum and Deficiency Content in Root Environment.Doklady. Biochemistry and biophysics · 2022Article
- Genome-Wide Associations with Resistance to Bipolaris Leaf Spot (Plants (Basel, Switzerland) · 2022Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mycotoxin deoxynivalenol (DON) acts as a disease virulence factor for Fusarium fungi, and tolerance of DON enhances wheat resistance to Fusarium head blight (FHB) disease. Two variants of an ATP-binding cassette (ABC) family C transporter gene were cloned from DON-treated wheat mRNA, namely TaABCC3.1 and TaABCC3.2. These represent two of three putative genes identified on chromosomes 3A, 3B, and 3D of the wheat genome sequence. Variant TaABCC3.1 represents the DON-responsive transcript previously associated with DON resistance in wheat. PCR-based mapping and in silico sequence analyses located TaABCC3.1 to the short arm of wheat chromosome 3B (not within the FHB resistance quantitative trait locus Fhb1). In silico analyses of microarray data indicated that TaABCC3 genes are expressed in reproductive tissue and roots, and in response to the DON producer Fusarium graminearum. Gene expression studies showed that TaABCC3.1 is activated as part of the early host response to DON and in response to the FHB defence hormone jasmonic acid. Virus-induced gene silencing (VIGS) confirmed that TaABCC3 genes contributed to DON tolerance. VIGS was performed using two independent viral construct applications: one specifically targeted TaABCC3.1 for silencing, while the other targeted this gene and the chromosome 3A homeologue. In both instances, VIGS resulted in more toxin-induced discoloration of spikelets, compared with the DON effects in non-silenced spikelets at 14 d after toxin treatment (≥2.2-fold increase, P<0.05). Silencing by both VIGS constructs enhanced head ripening, and especially so in DON-treated heads. VIGS of TaABCC3 genes also reduced the grain number by more than 28% (P<0.05), both with and without DON treatment, and the effects were greater for the construct that targeted the two homeologues. Hence, DON-responsive TaABCC3 genes warrant further study to determine their potential as disease resistance breeding targets and their function in grain formation and ripening.
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