ReviewNeuroscience bulletin2015
Hypothalamic-pituitary-adrenal axis function during perinatal depression.
Review in Neuroscience bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Potential Pleiotropic Genes and Shared Biological Pathways in Epilepsy and Depression Based on GWAS Summary Statistics.Computational intelligence and neuroscience · 2022Pooled it
- [Inflammatory Biomarkers and Postpartum Depression: A Systematic Review of Literature].Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2019Pooled it
- The association between maternal cortisol and depression during pregnancy, a systematic review.Archives of women's mental health · 2018Pooled it
- Association Between Systemic Inflammation Response Index and Specific Depressive Symptoms: Evidence From a Cross-Sectional Survey.Brain and behavior · 2026Article
- Depression, anxiety, and stress across the perinatal period: longitudinal trends and associations with adverse outcomes : Article Type: Original Paper.BMC pregnancy and childbirth · 2026Article
- Joint and Independent Associations of Gestational Diabetes and Depression With Childhood Obesity.JAMA network open · 2026Article
- Machine Learning-Based Prediction of Antepartum Depression Symptoms: A Prospective Cohort Study.International journal of women's health · 2026Article
- Neuroendocrine Regulation and Neural Circuitry of Parenthood: Integrating Neuropeptides, Brain Receptors, and Maternal Behavior.International journal of molecular sciences · 2025Review
- Pregnant Women Chronically Infected byPathogens (Basel, Switzerland) · 2025Article
- Association between maternal anxiety/depression in pregnancy and the development of offspring eczema/AD: a meta-analysis based on cohort studies.Frontiers in pediatrics · 2025Article
- Serotonin, cortisol, and DHEA-S levels in anxious and depressive pregnant women living with HIV.BMC psychology · 2024Article
- Association of depression with hypertensive left ventricular hypertrophy in age, sex, and education level-specific differences.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- The Cytokine, Chemokine, and Growth Factor Network of Prenatal Depression.Brain sciences · 2023Article
- The role of the hypothalamic-pituitary-adrenal axis in depression across the female reproductive lifecycle: current knowledge and future directions.Frontiers in endocrinology · 2023Review
- Prenatal stress, anxiety and depression alter transcripts, proteins and pathways associated with immune responses at the maternal-fetal interface†.Biology of reproduction · 2022Article
- The Value of HPA Axis Hormones as Biomarkers for Screening and Early Diagnosis of Postpartum Depression: Updated Information About Methodology.Frontiers in endocrinology · 2022Review
- Anxiety and depressive symptoms in pregnancy predict low birth weight differentially in male and female infants-findings from an urban pregnancy cohort in India.Social psychiatry and psychiatric epidemiology · 2021Article
- Role of midwife-supported psychotherapy on antenatal depression, anxiety and maternal health: A meta-analysis and literature review.Experimental and therapeutic medicine · 2020Article
- Cortisol and DHEA-S levels in pregnant women with severe anxiety.BMC psychiatry · 2020Article
- Association of antepartum depression, generalized anxiety, and posttraumatic stress disorder with infant birth weight and gestational age at delivery.Journal of affective disorders · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal function of the hypothalamic-pituitary-adrenal (HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol pro-inflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.