Evidence map›Paper›PMID 25732520›Full record

ReviewNature reviews. Endocrinology2015

MicroRNA regulatory networks in human adipose tissue and obesity.

Peter Arner, Agné Kulyté

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07512609 (Environment, Inflammation and Metabolic Diseases Study), which is not on this map. Cited by 261 papers.

0numbers the graph read from it
0cells of the map it votes in
261citing papers in PubMed
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07512609 recruitingnot on this mapstarted 2020, after this paper: background citation

Environment, Inflammation and Metabolic Diseases Study

Typeobservational_patient_registrySponsorQifu LiRan2020 to 2026Enrolled8,000ConditionsEndocrine Disease, Metabolic Disorders, Hypertension, Diabetes MellitusArmsobserve
3 · Its place in the literature

Who cites it

261 citing papers in PubMed, 458 citations in OpenAlex.

  1. Trial
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  9. Review
  10. 1α,25(OH)Nutrients · 2026
    Review
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  20. Type 2 Diabetes Mellitus Remission, Dream or Reality? A Narrative Review of Current Evidence and Integrated Care Strategies.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review

201 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peter ArnerLipid Laboratory, Department of Medicine Huddinge, Karolinska Institutet, SE-141 86 Stockholm, Sweden.
Agné KulytéLipid Laboratory, Department of Medicine Huddinge, Karolinska Institutet, SE-141 86 Stockholm, Sweden.
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and, therefore, biological processes in different tissues. A major function of miRNAs in adipose tissue is to stimulate or inhibit the differentiation of adipocytes, and to regulate specific metabolic and endocrine functions. Numerous miRNAs are present in human adipose tissue; however, the expression of only a few is altered in individuals with obesity and type 2 diabetes mellitus or are differentially expressed in various adipose depots. In humans, obesity is associated with chronic low-grade inflammation that is regulated by signal transduction networks, in which miRNAs, either directly or indirectly (through regulatory elements such as transcription factors), influence the expression and secretion of inflammatory proteins. In addition to their diverse effects on signalling, miRNAs and transcription factors can interact to amplify the inflammatory effect. Although additional miRNA signal networks in human adipose tissue are not yet known, similar regulatory circuits have been described in brown adipose tissue in mice. miRNAs can also be secreted from fat cells into the circulation and serve as markers of disturbed adipose tissue function. Given their role in regulating transcriptional networks, miRNAs in adipose tissue might offer tangible targets for treating metabolic disorders.

Indexed as

Gene Expression RegulationAdipogenesisAdipose TissueAnimalsCell DifferentiationChemokine CCL2Diabetes Mellitus, Type 2HumansInflammationInsulin ResistanceMiceMicroRNAsObesitySignal TransductionTranscription FactorsCCL2 protein, humanChemokine CCL2MicroRNAsTranscription Factors

Identifiers

PMID25732520
OpenAlexW2057217096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.