ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2015
Attenuation of cartilage pathogenesis in post-traumatic osteoarthritis (PTOA) in mice by blocking the stromal derived factor 1 receptor (CXCR4) with the specific inhibitor, AMD3100.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Association of organs-crosstalk with the pathogenesis of osteoarthritis: cartilage as a key player.Frontiers in endocrinology · 2025Review
- Cartilage Collagen Neoepitope C2C Expression in the Articular Cartilage and Its Relation to Joint Tissue Damage in Patients with Knee Osteoarthritis.Biomedicines · 2024Article
- Molecular biomarker approaches to prevention of post-traumatic osteoarthritis.Nature reviews. Rheumatology · 2024Review
- TCF12 regulates the TGF-β/Smad2/3 signaling pathway to accelerate the progression of osteoarthritis by targeting CXCR4.Journal of orthopaedic translation · 2024Article
- Macrophage phenotypes and monocyte subsets after destabilization of the medial meniscus in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Roles of long non‑coding RNA in osteoarthritis (Review).International journal of molecular medicine · 2021Review
- Endogenous Repair and Regeneration of Injured Articular Cartilage: A Challenging but Promising Therapeutic Strategy.Aging and disease · 2021Review
- The study of targeted blocking SDF-1/CXCR4 signaling pathway with three antagonists on MMPs, type II collagen, and aggrecan levels in articular cartilage of guinea pigs.Journal of orthopaedic surgery and research · 2020Article
- miR‑146a‑5p expression is upregulated by the CXCR4 antagonist TN14003 and attenuates SDF‑1‑induced cartilage degradation.Molecular medicine reports · 2019Article
- Stromal cell-derived factor-1 as a potential therapeutic target for osteoarthritis and rheumatoid arthritis.Therapeutic advances in chronic disease · 2019Review
- Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12.Bone research · 2019Article
- A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system.International journal of nanomedicine · 2018Article
- Establishment of rat ankle post-traumatic osteoarthritis model induced by malleolus fracture.BMC musculoskeletal disorders · 2017Article
- The Multifunctional Role of the Chemokine System in Arthritogenic Processes.Current rheumatology reports · 2017Review
- T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model.PloS one · 2017Article
- CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model.International journal of molecular sciences · 2016Article
- Inhibition of SDF-1α/CXCR4 Signalling in Subchondral Bone Attenuates Post-Traumatic Osteoarthritis.International journal of molecular sciences · 2016Article
- Musculoskeletal regeneration research network: A global initiative.Journal of orthopaedic translation · 2015Article
- Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice.Current rheumatology reports · 2015Review
- Advances in optical imaging for pharmacological studies.Frontiers in pharmacology · 2015Review
Corrections and comments
- Retraction · 2026-07-13Author Unresponsive · Concerns/Issues about Article · Concerns/Issues about Authorship/Affiliation · Duplication of/in Image · Investigation by Third Party · Unreliable Results and/or Conclusions · · See also: https://pubpeer.com/publications/0BE1B1D354C74EF8F60CDD464D207E
- Retracted
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
SDF-1 was found to infiltrate cartilage, decrease proteoglycan content, and increase MMP-13 activity after joint trauma. In this study, we tested the hypothesis that interference of the SDF-1/CXCR4 signaling pathway via AMD3100 can attenuate pathogenesis in a mouse model of PTOA. We also tested the predictive and confirmatory power of fluorescence molecular tomography (FMT) for cartilage assessment. AMD3100 was continuously delivered via mini-osmotic pumps. The extent of cartilage damage after AMD3100 or PBS treatment was assessed by histological analysis 2 months after PTOA was induced by surgical destabilization of the medial meniscus (DMM). Biochemical markers of PTOA were assessed via immunohistochemistry and in vivo fluorescence molecular tomography (FMT). Regression analysis was used to validate the predictive power of FMT measurements. Safranin-O staining revealed significant PTOA damage in the DMM/PBS mice, while the DMM/AMD3100 treated mice showed a significantly reduced response with minimal pathology. Immunohistochemistry showed that AMD3100 treatment markedly reduced typical PTOA marker expression in chondrocytes. FMT measurements showed decreased cathepsins and MMP activity in knee joints after treatment. The results demonstrate that AMD3100 treatment attenuates PTOA. AMD3100 may provide a viable and expedient option for PTOA therapy given the drug's FDA approval and well-known safety profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.