Evidence map›Paper›PMID 25732339›Full record

ReviewJournal of molecular microbiology and biotechnology2014

MukBEF, a chromosomal organizer.

Valentin V Rybenkov, Viridiana Herrera, Zoya M Petrushenko, Hang Zhao

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of molecular microbiology and biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Synthetic lethal mutants inJournal of bacteriology · 2023
    Pooled it
  2. Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  8. Review
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  11. Function and Evolution of the Loop Extrusion Machinery in Animals.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Article
  14. Conformation and dynamic interactions of the multipartite genome inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Ycs4 Subunit ofBiochemistry · 2021
    Article
  16. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Valentin V RybenkovDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Okla., USA.
Viridiana Herrera
Zoya M Petrushenko
Hang Zhao
University of Oklahoma · US

Funding

Structural Chromosome Maintenance in Pseudomonas aeruginosaR21AI094124 · NIAID · UNIVERSITY OF OKLAHOMA · PI RYBENKOV, VALENTIN V · 2011 to 2012
$413k
NIAID NIH HHS AI094124NIAID NIH HHS R21 AI094124
6 · The paper itself

Abstract

Global folding of bacterial chromosome requires the activity of condensins. These highly conserved proteins are involved in various aspects of higher-order chromatin dynamics in a diverse range of organisms. Two distinct superfamilies of condensins have been identified in bacteria. The SMC-ScpAB proteins bear significant homology to eukaryotic condensins and cohesins and are found in most of the presently sequenced bacteria. This review focuses on the MukBEF/MksBEF superfamily, which is broadly distributed across diverse bacteria and is characterized by low sequence conservation. The prototypical member of this superfamily, the Escherichia coli condensin MukBEF, continues to provide critical insights into the mechanism of the proteins. MukBEF acts as a complex molecular machine that assists in chromosome segregation and global organization. The review focuses on the mechanistic analysis of DNA organization by MukBEF with emphasis on its involvement in the formation of chromatin scaffold and plausible other roles in chromosome segregation.

Indexed as

ChromatinChromosomal Proteins, Non-HistoneChromosomes, BacterialChromosome SegregationDNA, BacterialEscherichia coliEscherichia coli ProteinsRepressor ProteinsChromatinChromosomal Proteins, Non-HistoneDNA, BacterialEscherichia coli ProteinsMukB protein, E colimukE protein, E colimukF protein, E coliRepressor Proteins

Identifiers

PMID25732339
PMCPMC4377647
OpenAlexW2006126077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.