ReviewThe journal of nutrition, health & aging2015
Cognitive aspects of frailty: mechanisms behind the link between frailty and cognitive impairment.
Review in The journal of nutrition, health & aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association Between Frailty and Cognitive Impairment in Chronic Kidney Disease: A Systematic Review and Meta-Analysis.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026Pooled it
- Effectiveness of interventions to prevent pre-frailty and frailty progression in older adults: a systematic review.JBI database of systematic reviews and implementation reports · 2018Pooled it
- Independent association between subjective cognitive decline and frailty in the elderly.PloS one · 2018Trial
- The Mediating Effect of Sleep Quality on the Relationship Between Frailty and Cognitive Impairment Among Community-Dwelling Older Adults: A Cross-Sectional Study.Nursing open · 2026Article
- Mild cognitive impairment and pre-frailty show distinct plasma multi-omic signatures: a cross-sectional study.GeroScience · 2026Article
- Longitudinal association between dietary quality trajectories and cognitive frailty in older adults: a 12-year study of the TIGER cohort.GeroScience · 2026Article
- Frailty, trajectories of frailty, and cognitive impairment: evidence from five longitudinal cohort studies.BMC public health · 2026Article
- Ketogenic diet enhances cognitive-behavioral function and hippocampal neurogenesis while attenuating amyloid pathology in Tg-SwDI mice.Journal of Alzheimer's disease : JAD · 2026Article
- Effects of Sarcopenia and Frailty on Cognitive Function, Brain Volume, and Dementia Risk: A Prospective Cohort Study Based on UK Biobank.Dementia and neurocognitive disorders · 2026Article
- Associations between cognitive frailty and circulating cardiovascular biomarkers in a memory clinic cohort.GeroScience · 2026Article
- Preventing Cognitive Frailty: What People Know and What They Are Willing to Change.Brain and behavior · 2026Article
- Preserved muscle function as a protective factor against cognitive decline: Longitudinal results from the FINGER study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Nutritional intervention targeting muscle-brain axis in dementia continuum: from mechanisms to practice.Frontiers in nutrition · 2026Review
- Detection of social frailty in older adults: validation and reliability of the Makizako Social Frailty Index for Turkish older adults, a cross-sectional study.BMC geriatrics · 2025Article
- Association between frailty and cognitive function: a pooled analysis of three ageing cohorts.Translational psychiatry · 2025Article
- Development and testing of an electronic frailty index using Canadian electronic medical record data in primary care.BMC primary care · 2025Article
- Associations of neurodegenerative and cerebrovascular neuropathology with frailty in a diverse sample.Acta neuropathologica communications · 2025Article
- Relationships between physical frailty, depressive symptoms, and cognitive ability among community-dwelling older adults in India.BMC public health · 2025Article
- Predicting cognitive frailty in community-dwelling older adults: a machine learning approach based on multidomain risk factors.Scientific reports · 2025Article
- Associations between oral health measures and cognitive function in middle aged and older Indian adults.Scientific reports · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whereas physical impairment is the main hallmark of frailty, evidence suggests that other dimensions, such as psychological, cognitive and social factors also contribute to this multidimensional condition. Cognition is now considered a relevant domain of frailty. Cognitive and physical frailty interact: cognitive problems and dementia are more prevalent in physically frail individuals, and those with cognitive impairment are more prone to become frail. Disentangling the relationship between cognition and frailty may lead to new intervention strategies for the prevention and treatment of both conditions. Both frailty and cognitive decline share common potential mechanisms. This review examines the relationship between frailty and cognitive decline and explores the role of vascular changes, hormones, vitamin D, inflammation, insulin resistance, and nutrition in the development of physical frailty and cognitive problems, as potential underlying mechanisms behind this link. Dual tasking studies may be a useful way to explore and understand the relation between cognitive and physical frailty. Further studies are needed to elucidate this complex relation to improve the outcomes of frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.