ArticleMolecular microbiology2015
ArsH is an organoarsenical oxidase that confers resistance to trivalent forms of the herbicide monosodium methylarsenate and the poultry growth promoter roxarsone.
Article in Molecular microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 195 citations in OpenAlex.
- Synergistic function of ars genes in arsenic detoxification and biosynthesis of organoarsenicals.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Rafts of change: microbial and functional dynamics in simulatedApplied and environmental microbiology · 2026Article
- Microbial functional traits in the hyperaccumulating Noccaea praecox rhizobiome are metal-dependent and host-driven.Environmental microbiome · 2026Article
- Mechanisms of Arsenic Interaction inInternational journal of molecular sciences · 2025Review
- Physicochemistry and comparative metagenomics of a tropical estuary persistently inundated with anthropogenic pollutants.Folia microbiologica · 2025Article
- Article
- Flavin-dependent enzymatic and photochemical interconversions between phenylarsonic and phenylarsonous acids.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Distinct bacterial community structures and arsenic biotransformation gene profiles in dust.Frontiers in microbiology · 2025Article
- Genome Deletions and Rewiring of the Transcriptome Underlying High Antimonite Resistance inInternational journal of molecular sciences · 2024Article
- Pavlovian-Type Learning in Environmental Bacteria: Regulation of Herbicide Resistance by Arsenic in Pseudomonas putida.Environmental microbiology · 2024Article
- SULF1 regulates malignant progression of colorectal cancer by modulating ARSH via FAK/PI3K/AKT/mTOR signaling.Cancer cell international · 2024Article
- Adaptation to metal(loid)s in strain Mucilaginibacter rubeus P2 involves novel arsenic resistance genes and mechanisms.Journal of hazardous materials · 2024Article
- Purifying selection drives distinctive arsenic metabolism pathways in prokaryotic and eukaryotic microbes.ISME communications · 2024Article
- Mechanisms of emerging resistance associated with non-antibiotic antimicrobial agents: a state-of-the-art review.The Journal of antibiotics · 2023Review
- Widespread Distribution of theEnvironmental science & technology · 2023Article
- Arsenite Methyltransferase Diversity and Optimization of Methylation Efficiency.Environmental science & technology · 2023Article
- Host-adaptive traits in the plant-colonizing Pseudomonas donghuensis P482 revealed by transcriptomic responses to exudates of tomato and maize.Scientific reports · 2023Article
- Bifunctional protein ArsRBMC microbiology · 2023Article
- Arsenic in medicine: past, present and future.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Review
- Unexpected genetic and microbial diversity for arsenic cycling in deep sea cold seep sediments.NPJ biofilms and microbiomes · 2023Review
23 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Environmental organoarsenicals are produced by microorganisms and are introduced anthropogenically as herbicides and antimicrobial growth promoters for poultry and swine. Nearly every prokaryote has an ars (arsenic resistance) operon, and some have an arsH gene encoding an atypical flavodoxin. The role of ArsH in arsenic resistance has been unclear. Here we demonstrate that ArsH is an organoarsenical oxidase that detoxifies trivalent methylated and aromatic arsenicals by oxidation to pentavalent species. Escherichia coli, which does not have an arsH gene, is very sensitive to the trivalent forms of the herbicide monosodium methylarsenate [MSMA or MAs(V)] and antimicrobial growth promoter roxarsone [Rox(V)], as well as to phenylarsenite [PhAs(III), also called phenylarsine oxide or PAO]. Pseudomonas putida has two chromosomally encoded arsH genes and is highly resistant to the trivalent forms of these organoarsenicals. A derivative of P. putida with both arsH genes deleted is sensitive to MAs(III), PhAs(III) or Rox(III). P. putida arsH expressed in E. coli conferred resistance to each trivalent organoarsenical. Cells expressing PpArsH oxidized the trivalent organoarsenicals. PpArsH was purified, and the enzyme in vitro similarly oxidized the trivalent organoarsenicals. These results suggest that ArsH catalyzes a novel biotransformation that confers resistance to environmental methylated and aromatic arsenicals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.