ArticlePhysiology & behavior2015
Pituitary CRH-binding protein and stress in female mice.
Article in Physiology & behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Consensus Pituitary Atlas, a scalable resource for annotation, novel marker discovery, and analyses in mouse pituitary gland research.Cell reports · 2026Article
- HPA/HPG axes dysfunction: assessing the interrelations between diminished ovarian reserve and mental health.Journal of ovarian research · 2026Review
- Mild Neonatal Hypoxia Modifies the Reactivity of the Glucocorticoid System in Adult Rats, Promoting Improved Learning and Spatial Memory Under Stressful Conditions.Neurochemical research · 2026Article
- Role of CRH in colitis and colitis-associated cancer: a combinative result of central and peripheral effects?Frontiers in endocrinology · 2024Review
- Brain imaging derived phenotypes: a biomarker for the onset of inflammatory bowel disease and a potential mediator of mental complications.Frontiers in immunology · 2024Article
- Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland.Biology of sex differences · 2022Article
- Article
- Sex Differences in Acute Neuroendocrine Responses to Stressors in Rodents and Humans.Cold Spring Harbor perspectives in biology · 2022Article
- Considering Sex as a Biological Variable in Basic and Clinical Studies: An Endocrine Society Scientific Statement.Endocrine reviews · 2021Article
- Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research.Frontiers in behavioral neuroscience · 2021Review
- Deficits across multiple behavioral domains align with susceptibility to stress in 129S1/SvImJ mice.Neurobiology of stress · 2020Article
- Role of corticotropin-releasing factor in alcohol and nicotine addiction.Brain research · 2020Review
- Sex differences in corticotropin releasing factor regulation of medial septum-mediated memory formation.Neurobiology of stress · 2019Article
- Maternal stress and the MPOA: Activation of CRF receptor 1 impairs maternal behavior and triggers local oxytocin release in lactating rats.Neuropharmacology · 2018Article
- Hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes: sex differences in regulation of stress responsivity.Stress (Amsterdam, Netherlands) · 2017Review
- Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans.Stress (Amsterdam, Netherlands) · 2017Review
- Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases.Brain, behavior, and immunity · 2017Article
- Cell Type-Specific Expression of Corticotropin-Releasing Hormone-Binding Protein in GABAergic Interneurons in the Prefrontal Cortex.Frontiers in neuroanatomy · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The CRH-binding protein (CRH-BP) binds CRH with very high affinity and inhibits CRH-mediated ACTH release from anterior pituitary cells in vitro, suggesting that the CRH-BP functions as a negative regulator of CRH activity. Our previous studies have demonstrated sexually dimorphic expression of CRH-BP in the murine pituitary. Basal CRH-BP expression is higher in the female pituitary, where CRH-BP mRNA is detected in multiple anterior pituitary cell types. In this study, we examined stress-induced changes in CRH-BP mRNA and protein expression in mouse pituitary and assessed the in vivo role of CRH-BP in modulating the stress response. Pituitary CRH-BP mRNA was greater than 200-fold more abundant in females than males, and restraint stress increased pituitary CRH-BP mRNA by 11.8-fold in females and 3.2-fold in males as assessed by qRT-PCR. In females, restraint stress increased CRH-BP mRNA levels not only in POMC-expressing cells, but also in PRL-expressing cells. The increase in female pituitary CRH-BP mRNA following stress resulted in significant increases in CRH-BP protein 4-6h after a 30-minute restraint stress as detected by [(125)I]-CRH:CRH-BP cross-linking analyses. Based on this temporal profile, the physiological role of CRH-BP was assessed using a stressor of longer duration. In lipopolysaccharide (LPS) stress studies, female CRH-BP-deficient mice showed elevated levels of stress-induced corticosterone release as compared to wild-type littermates. These studies demonstrate a role for the pituitary CRH-BP in attenuating the HPA response to stress in female mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.