Trial reportIndian journal of pediatrics2015
Nebulized Magnesium Sulfate in Acute Bronchiolitis: A Randomized Controlled Trial.
Trial report in Indian journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Magnesium sulphate for treating acute bronchiolitis in children under two years of age.The Cochrane database of systematic reviews · 2026Pooled it
- Magnesium sulphate for treating acute bronchiolitis in children up to two years of age.The Cochrane database of systematic reviews · 2020Pooled it
- Complementary and alternative medicine for the treatment of bronchiolitis in infants: A systematic review.PloS one · 2017Pooled it
- Nebulized Magnesium Sulfate for Treatment of Persistent Pulmonary Hypertension of Newborn: A Pilot Randomized Controlled Trial.Indian journal of pediatrics · 2021Trial
- Trial
- Is Intravenous Magnesium Sulfate Beneficial in Children with Acute Asthma Exacerbation and Acute Bronchiolitis? A Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Efficacies of different treatment strategies for infants hospitalized with acute bronchiolitis.Clinical and experimental pediatrics · 2024Article
- Inhaled Magnesium in Acute Bronchiolitis: Another One Bites the Dust?Indian journal of pediatrics · 2021Article
- Acute Bronchiolitis: Still No New Treatments to Offer.Indian journal of pediatrics · 2015Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the efficacy of nebulized magnesium sulfate as a bronchodilator in infants hospitalized with acute bronchiolitis.
methodsThis three-center double masked randomized clinical trial comprised 120 children with moderate to severe bronchiolitis. They were randomly assigned into two groups: the first group was treated with nebulized magnesium sulfate (40 mg/kg) and nebulized epinephrine (0.1 ml/kg) and the second group (control) was treated with nebulized epinephrine (0.1 ml/kg). The primary outcome was the length of hospital stay. The use of oxygen, temperature, oxygen saturation (SPO2), pulse rate (PR), respiratory rate (RR) and respiratory distress assessment instrument (RDAI) score were measured in the beginning of the study and during hospitalization.
resultsThe mean (SD) age of 120 infants was 5.1(± 2.6) mo and 60% were boys. The length of hospital stay was not different between the two groups (P > 0.01). Use of oxygen supplementation, SPO2 and vital signs were similar in the two groups. Improvement in RDAI score was significantly better in infants treated with nebulized magnesium sulfate than in the other group (P 0.01).
conclusionsThus, in infants with acute bronchiolitis, the effect of nebulized magnesium sulfate is comparable to nebulized epinephrine. However nebulized magnesium sulfate can improve the clinical score so it may have additive effect to reduce symptoms during hospitalization.
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