ArticleSchizophrenia bulletin2015
Cognitive Effort and Schizophrenia Modulate Large-Scale Functional Brain Connectivity.
Article in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Article
- Article
- Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology.Biological psychiatry · 2022Article
- Impaired attentional modulation of sensorimotor control and cortical excitability in schizophrenia.Brain : a journal of neurology · 2019Article
- Consistent Functional Connectivity Alterations in Schizophrenia Spectrum Disorder: A Multisite Study.Schizophrenia bulletin · 2017Article
- Altered brain connectivity in patients with schizophrenia is consistent across cognitive contexts.Journal of psychiatry & neuroscience : JPN · 2017Article
- Global brain connectivity alterations in patients with schizophrenia and bipolar spectrum disorders.Journal of psychiatry & neuroscience : JPN · 2016Article
- Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders.NeuroImage. Clinical · 2016Article
- Assessing brain structural associations with working-memory related brain patterns in schizophrenia and healthy controls using linked independent component analysis.NeuroImage. Clinical · 2015Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia (SZ) is characterized by cognitive dysfunction and disorganized thought, in addition to hallucinations and delusions, and is regarded a disorder of brain connectivity. Recent efforts have been made to characterize the underlying brain network organization and interactions. However, to which degree connectivity alterations in SZ vary across different levels of cognitive effort is unknown. Utilizing independent component analysis (ICA) and methods for delineating functional connectivity measures from functional magnetic resonance imaging (fMRI) data, we investigated the effects of cognitive effort, SZ and their interactions on between-network functional connectivity during 2 levels of cognitive load in a large and well-characterized sample of SZ patients (n = 99) and healthy individuals (n = 143). Cognitive load influenced a majority of the functional connections, including but not limited to fronto-parietal and default-mode networks, reflecting both decreases and increases in between-network synchronization. Reduced connectivity in SZ was identified in 2 large-scale functional connections across load conditions, with a particular involvement of an insular network. The results document an important role of interactions between insular, default-mode, and visual networks in SZ pathophysiology. The interplay between brain networks was robustly modulated by cognitive effort, but the reduced functional connectivity in SZ, primarily related to an insular network, was independent of cognitive load, indicating a relatively general brain network-level dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.