ReviewCurrent opinion in biotechnology2015
A roadmap for interpreting (13)C metabolite labeling patterns from cells.
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Review in Current opinion in biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 367 papers, 1 of them a synthesis that pooled it.
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367citing papers in PubMed, 1 pooled it
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Who cites it
367 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Polyploid cancer cells surviving cisplatin reallocate central carbon sources to fuel antioxidant metabolism for survival.Molecular metabolism · 2026Article
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- Decoding cancer across scales with metabolomics.Nature reviews. Cancer · 2026Review
- A Stable Isotope Tracing Primer for the Mass Spectrometrist.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026Review
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- Alpha-ketoglutarate enhances adipose-derived stem cells survival in wound healing by hypoxia-inducible factor 1-alpha-mediated redox homeostasis and glycogen-dependent bioenergetics.World journal of stem cells · 2026Article
- Article
307 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors.
Joerg M BuescherVesalius Research Center, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium.
Maciek R AntoniewiczDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, USA.
Laszlo G BorosDepartment of Pediatrics, UCLA School of Medicine, Los Angeles Biomedical Research Institute at the Harbor-UCLA Medical Center and Sidmap, LLC, Los Angeles, CA, USA.
Shawn C BurgessAdvanced Imaging Research Center-Division of Metabolic Mechanisms of Disease and Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Henri BrunengraberDepartment of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Clary B ClishBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Ralph J DeBerardinisChildren's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Olivier FeronPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Brussels, Belgium.
Christian FrezzaMRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Bart GhesquiereVesalius Research Center, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium.
Eyal GottliebCancer Research UK, Beatson Institute, Glasgow, UK.
Karsten HillerLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg.
Russell G JonesGoodman Cancer Research Centre, Department of Physiology, McGill University, Montreal, QC, Canada.
Jurre J KamphorstInstitute of Cancer Sciences, University of Glasgow, Glasgow, UK.
Richard G KibbeyInternal Medicine, Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
Alec C KimmelmanDivision of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jason W LocasaleDivision of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Sophia Y LuntDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Oliver D K MaddocksCancer Research UK, Beatson Institute, Glasgow, UK.
Craig MalloyAdvanced Imaging Research Center-Division of Metabolic Mechanisms of Disease and Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Christian M MetalloDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Emmanuelle J MeuilletL'Institut des Technologies Avancées en Sciences du Vivant (ITAV), Toulouse Cedex 1, France; The University of Arizona Cancer Center, and Department of Nutritional Sciences, The University of Arizona, Tucson, AZ, USA.
Joshua MungerDepartment of Biochemistry, University of Rochester Medical Center, Rochester, NY, USA; Department of Biophysics, University of Rochester Medical Center, Rochester, NY, USA.
Katharina NöhInstitute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich GmbH, Jülich, Germany.
Joshua D RabinowitzDepartment of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Markus RalserCambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Cambridge, UK; Division of Physiology and Metabolism, MRC National Institute for Medical Research, London, UK.
Uwe SauerInstitute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Gregory StephanopoulosDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Julie St-PierreGoodman Cancer Research Centre, and Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
Daniel A TennantSchool of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
Christoph WittmannInstitute of Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Matthew G Vander HeidenKoch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Alexei VazquezCancer Research UK, Beatson Institute, Glasgow, UK.
Karen VousdenCancer Research UK, Beatson Institute, Glasgow, UK.
Jamey D YoungDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Nicola ZamboniInstitute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Sarah-Maria FendtVesalius Research Center, VIB, Leuven, Belgium; Department of Oncology, KU Leuven, Leuven, Belgium. Electronic address: sarah-maria.fendt@vib-kuleuven.be.
Funding
Factors controlling metabolic flux in the liver - Supplement RevisionR01DK078184 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Shawn C Burgess · 2008 to 2026
$6.8MA Clinical MR Scanner for Imaging Hyperpolarized Carbon-13S10RR029119 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2011 to 2011
$2.2MMETABOLIC REGULATORS OF TUMOR CELL GROWTHR01CA157996 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI DEBERARDINIS, RALPH J · 2011 to 2017
$2.2MThe role of the mitochondrial GTP cycle in insulin secretionR01DK092606 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G · 2011 to 2015
$1.8MMetabolic regulatory mechanisms essential for Human Cytomegalovirus replicationR01AI081773 · NIAID · UNIVERSITY OF ROCHESTER · PI MUNGER, JOSHUA C · 2010 to 2014
$1.7MHypoxia-induced Metabolic Changes in CancerR01CA160458 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI ILIOPOULOS, OTHON, STEPHANOPOULOS, GREGORY · 2012 to 2016
$1.6MA Clinical Polarizer for Carbon-13 (SpinLab)S10OD018468 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2015 to 2015
$1.0MUnderstanding metabolic flux and the control of mammalian cell growthR00CA168997 · NCI · DUKE UNIVERSITY · PI LOCASALE, JASON W. · 2013 to 2015
$695kMetabolic regulatory mechanisms essential for Human Cytomegalovirus replicationR56AI081773 · NIAID · UNIVERSITY OF ROCHESTER · PI MUNGER, JOSHUA C · 2015 to 2015
$384kCancer Research UK 17728Cancer Research UK 18274Cancer Research UK 18278Cancer Research UK 19702Cancer Research UK 21140Medical Research Council MC_UP_1101/3Medical Research Council MC_UU_12022/6NCI NIH HHS R00 CA168997NCI NIH HHS R01 CA157996NCI NIH HHS R01 CA160458NCRR NIH HHS S10 RR029119NIAID NIH HHS R01 AI081773NIAID NIH HHS R56 AI081773NIDDK NIH HHS R01 DK078184NIDDK NIH HHS R01 DK092606
Abstract
Measuring intracellular metabolism has increasingly led to important insights in biomedical research. (13)C tracer analysis, although less information-rich than quantitative (13)C flux analysis that requires computational data integration, has been established as a time-efficient method to unravel relative pathway activities, qualitative changes in pathway contributions, and nutrient contributions. Here, we review selected key issues in interpreting (13)C metabolite labeling patterns, with the goal of drawing accurate conclusions from steady state and dynamic stable isotopic tracer experiments.
Indexed as
Metabolic Networks and PathwaysAnimalsCarbon IsotopesCell SurvivalHumansIsotope LabelingCarbon Isotopes
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