ReviewIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2015
Immunohistochemical study of MUC1, MUC2 and MUC5AC in colorectal carcinoma and review of literature.
Review in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Clinicopathological and prognostic significance of mucin signatures in lower gastrointestinal cancer-a systematic review and meta-analysis.British journal of cancer · 2026Pooled it
- MUC21 is downregulated in oral squamous cell carcinoma and associated with poor prognosis.Frontiers in oncology · 2026Article
- Proinflammatory Microenvironment in Adenocarcinoma Tissue of Colorectal Carcinoma.International journal of molecular sciences · 2024Article
- Characterizing and forecasting neoantigens-resulting from MUC mutations in COAD.Journal of translational medicine · 2024Article
- Research Progress of SN38 Drug Delivery System in Cancer Treatment.International journal of nanomedicine · 2024Review
- Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota.Cell & bioscience · 2023Review
- Review
- Article
- MUC1: Structure, Function, and Clinic Application in Epithelial Cancers.International journal of molecular sciences · 2021Review
- Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer.Medical molecular morphology · 2021Article
- Cancer Immunoprevention: Current Status and Future Directions.Archivum immunologiae et therapiae experimentalis · 2021Review
- MUC1 and MUC5AC implication in Tunisian colorectal cancer patientsTurkish journal of medical sciences · 2021Article
- Quantitative assessment of the diagnostic role of mucin family members in pancreatic cancer: a meta-analysis.Annals of translational medicine · 2021Article
- The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer.Cancer management and research · 2021Review
- Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth.Nature microbiology · 2020Article
- Mucin-1 expression and localization in epithelial cells shows characteristic and distinct patterns in inflammatory bowel diseases and colorectal cancer.International journal of clinical and experimental pathology · 2019Article
- Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival.PloS one · 2019Article
- Differential expression of mucin 1 and mucin 2 in colorectal cancer.World journal of gastroenterology · 2018Article
- Ramifications of secreted mucin MUC5AC in malignant journey: a holistic view.Carcinogenesis · 2018Review
- Loss and gain of N-linked glycosylation sequons due to single-nucleotide variation in cancer.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA hallmark of colorectal carcinomas is their ability to secrete mucus. Aberrant expression of mucins and alterations in their glycosylation are associated with the development and progression of malignant diseases. Therefore, mucins can be used as markers of malignancy. Tumor-associated mucins are also used as immunotargets in the treatment of cancer. The present work aimed to study the patterns of expression of MUC1, MUC2 and MUC5AC in colorectal carcinoma using immunohistochemistry and their relationship with site, histological differentiation and stage.
methodsFifty cases of colorectal carcinoma were chosen for the study. The histopathology slides were reviewed and blocks were retrieved. Using manual method, tissue microarray blocks were prepared. Immunostaining for MUC1, MUC2 and MUC5AC was performed on slides cut from the tissue microarray block.
resultsWe found that MUC1 expression was upregulated to 39 %, MUC2 expression was downregulated to 43 % and MUC5AC was aberrantly expressed in 24 % of colorectal cancer (CRC). There was a significant correlation between MUC1 positivity and tumor differentiation. As the grade increased from well to moderately differentiated, MUC1 expression increased from 11 % to 55 % (p-value 0.01). There was a statistically significant difference between MUC5AC positivity and grade of tumor (p-value 0.006). The percentage of cases showing MUC5AC expression increased as the stage of disease progressed from 1 to 4. However, there was no significant difference in MUC5AC positivity and stage of CRC (p-value 0.77).
conclusionWe do not find any correlation between tumor stage or site and MUC1, MUC2 or MUC5AC expression. MUC1and MUC5AC expression showed significant correlation with tumor grade.
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