ArticleMedical oncology (Northwood, London, England)2015
Down-expression pattern of Ku70 and p53 coexisted in colorectal cancer.
Article in Medical oncology (Northwood, London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- High-Throughput Mass Spectrometry Analysis ofJournal of proteome research · 2024Article
- Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome.Science advances · 2024Article
- The role of the PTEN/mTOR axis in clinical response of rectal cancer patients.Molecular biology reports · 2022Article
- Review
- Article
- Writing, erasing and reading histone lysine methylations.Experimental & molecular medicine · 2017Review
- Combined detection of the expression of Nm23-H1 and p53 is correlated with survival rates of patients with stage II and III colorectal cancer.Oncology letters · 2017Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To address the relationship of altered expression of double-strand break repair proteins Ku70 and p53 in clinical colorectal cancer (CRC), we examined the expression pattern of Ku70 and p53 by using fluorescent immunohistochemistry and real-time PCR assays in CRC and pericancerous samples from 152 Chinese patients. The results showed that down-expression pattern of both Ku70 and p53 coexisted in the CRC samples with significant correlating rate (R (2) = 0.9103; P < 0.001), and the down-expression of Ku70 and p53 was significantly associated with the advanced tumor node metastasis stage (Ku70: HR 3.453 in recurrence and 4.182 in survival, P < 0.001; P53: HR 3.114 in recurrence and 4.113 in survival, P < 0.001). The down-regulated Ku70 and p53 were associated with poor disease-free survival. Loss of Ku70 and p53 expression might serve as a biomarker of poor prognosis in CRC patients.
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