Evidence map›Paper›PMID 25731159›Full record

ArticleNature2015

A gp130-Src-YAP module links inflammation to epithelial regeneration.

Koji Taniguchi, Li-Wha Wu, Sergei I Grivennikov, Petrus R de Jong, Ian Lian, Fa-Xing Yu, Kepeng Wang, Samuel B Ho, Brigid S Boland, John T Chang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 405 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
405citing papers in PubMed, 2 pooled it
28.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

405 citing papers in PubMed, 2 syntheses or guidelines pooled it, 623 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Building and regenerating intestines by manipulating intestinal stem cells.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  10. Article
  11. Observational
  12. Signaling pathways regulating cardiac regeneration.Cell regeneration (London, England) · 2026
    Review
  13. Review
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  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

345 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Koji Taniguchi1] Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA [2] Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, California 92093, USA [3] Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan [4] Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Li-Wha Wu1] Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA [2] Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Sergei I Grivennikov1] Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA [2] Fox Chase Cancer Center, Cancer Prevention and Control Program, Philadelphia, Pennsylvania 19111, USA.
Petrus R de JongDepartment of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Ian Lian1] Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, California 92093, USA [2] Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA [3] Department of Biology, Lamar University, PO Box 10037, Beaumont, Texas 77710, USA.
Fa-Xing Yu1] Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, California 92093, USA [2] Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA [3] Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Kepeng WangLaboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA.
Samuel B HoDepartment of Medicine, VA San Diego Healthcare System, San Diego, California 92161, USA.
Brigid S BolandInflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
John T ChangInflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
William J SandbornInflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Gary Hardiman1] Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA [2] CSRC and BIMRC, San Diego State University, San Diego, California 92182, USA.
Eyal RazDepartment of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Yoshihiko MaeharaDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Akihiko Yoshimura1] Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan [2] Japan Science and Technology Agency, CREST, Tokyo 102-0076, Japan.
Jessica Zucman-Rossi1] Inserm, UMR 1162, Génomique fonctionnelle des tumeurs solides, IUH, Paris 75010, France [2] Université Paris Descartes, Labex Immuno-oncology, Sorbonne Paris Cité, Faculté de Medicine, Paris 75006, France.
Kun-Liang Guan1] Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, California 92093, USA [2] Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
Michael Karin1] Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA [2] Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, California 92093, USA [3] Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
University of California, San Diego · USInserm · FRKeio University · JPKyushu University · JPMedical University of South Carolina · USVA San Diego Healthcare System · US

Funding

Training Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7M
Role of Inflammation in tumor promotion and progressionR01CA118165 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARIN, MICHAEL · 2007 to 2016
$4.6M
Regulation and function of the YAP transcription co-activator oncoproteinR01CA132809 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUAN, KUN-LIANG · 2008 to 2015
$2.6M
Regulation and Function of Polarity and Asymmetric Cell Division in ImmunityR01AI095277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, JOHN T · 2012 to 2016
$2.6M
Understanding the Basis for Cellular Diversity During Adaptive ImmunityDP2OD008469 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, JOHN T · 2011 to 2011
$2.3M
Regulation of the Hippo pathway and its role in uveal melanomaR01EY022611 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUAN, KUN-LIANG · 2012 to 2015
$1.5M
The Role of Interleukin 23 In Colitis Associated CancerR00DK088589 · NIDDK · RESEARCH INST OF FOX CHASE CAN CTR · PI GRIVENNIKOV, SERGEI I · 2013 to 2015
$728k
NCI NIH HHS CA118165-09NCI NIH HHS CA132809NCI NIH HHS R01 CA118165NEI NIH HHS EY022611NIAID NIH HHS R01 AI095277NIDDK NIH HHS R00 DK088589NIDDK NIH HHS T32 DK007202NIH HHS DP2 OD008469
6 · The paper itself

Abstract

Inflammation promotes regeneration of injured tissues through poorly understood mechanisms, some of which involve interleukin (IL)-6 family members, the expression of which is elevated in many diseases including inflammatory bowel diseases and colorectal cancer. Here we show in mice and human cells that gp130, a co-receptor for IL-6 cytokines, triggers activation of YAP and Notch, transcriptional regulators that control tissue growth and regeneration, independently of the gp130 effector STAT3. Through YAP and Notch, intestinal gp130 signalling stimulates epithelial cell proliferation, causes aberrant differentiation and confers resistance to mucosal erosion. gp130 associates with the related tyrosine kinases Src and Yes, which are activated on receptor engagement to phosphorylate YAP and induce its stabilization and nuclear translocation. This signalling module is strongly activated upon mucosal injury to promote healing and maintain barrier function.

Indexed as

RegenerationAdaptor Proteins, Signal TransducingAnimalsBody WeightCell Cycle ProteinsCell DifferentiationCell ProliferationCytokine Receptor gp130Disease Models, AnimalEnzyme ActivationEpithelial CellsHEK293 CellsHomeostasisHumansInflammationInflammatory Bowel DiseasesAdaptor Proteins, Signal TransducingCell Cycle ProteinsCytokine Receptor gp130PhosphoproteinsProto-Oncogene Proteins c-yesProto-Oncogene Proteins pp60(c-src)Receptors, NotchYap1 protein, mouseYAP-Signaling Proteins

Identifiers

PMID25731159
PMCPMC4447318
OpenAlexW2072304718

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.