ArticleEnvironmental science and pollution research international2015
Chronic exposures to low and high concentrations of ibuprofen elicit different gene response patterns in a euryhaline fish.
Article in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 56 citations in OpenAlex.
- Ibuprofen as an emerging organic contaminant in environment, distribution and remediation.Heliyon · 2020Review
- Biodegradation aspects of ibuprofen and identification of ibuprofen-degrading microbiota in an immobilized cell bioreactor.Environmental science and pollution research international · 2019Article
- Developmental exposure to environmentally relevant concentrations of bifenthrin alters transcription of mTOR and ryanodine receptor-dependent signaling molecules and impairs predator avoidance behavior across early life stages in inland silversides (Menidia beryllina).Aquatic toxicology (Amsterdam, Netherlands) · 2019Article
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- Toxicity and biodegradation of ibuprofen by Bacillus thuringiensis B1(2015b).Environmental science and pollution research international · 2017Article
- Drugs of environmental concern modify Solea senegalensis physiology and biochemistry in a temperature-dependent manner.Environmental science and pollution research international · 2016Article
- Changes in Menidia beryllina Gene Expression and In Vitro Hormone-Receptor Activation After Exposure to Estuarine Waters Near Treated Wastewater Outfalls.Archives of environmental contamination and toxicology · 2016Article
- Molecular and cellular effects of contamination in aquatic ecosystems.Environmental science and pollution research international · 2015Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ibuprofen is one of the most commonly detected pharmaceuticals in wastewater effluent; however, the effects of ibuprofen on aquatic organisms are poorly understood. This study presents the transcriptome-wide response of the inland silverside, Menidia beryllina, to chronic exposure to ibuprofen. At the lowest exposure concentration (0.0115 mg/L), we detected a downregulation of many genes involved in skeletal development, aerobic respiration, and immune function. At the highest exposure concentration (1.15 mg/L), we detected increased expression of regulatory genes in the arachidonic acid metabolism pathway and several immune genes involved in an inflammatory response. Additionally, there was differential expression of genes involved in oxidative stress responses and a downregulation of genes involved in osmoregulation. This study provides useful information for monitoring the effects of this common wastewater effluent contaminant in the environment and for the generation of biomarkers of exposure to ibuprofen that may be transferable to other fish species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.