Evidence map›Paper›PMID 25731070›Full record

ArticleHemodialysis international. International Symposium on Home Hemodialysis2015

Prevalence and correlates of functional dependence among maintenance dialysis patients.

Niall T Kavanagh, Brigitte Schiller, Anjali B Saxena, I-Chun Thomas, Manjula Kurella Tamura

2 registry-linked trialsAbstract read
In one paragraph

Article in Hemodialysis international. International Symposium on Home Hemodialysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07033611 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Creatine Supplementation in Sarcopenic and Non-sarcopenic Patients on Chronic Hemodialysis

TypeinterventionalSponsorCarla Basualto AlarcónRan2024 to 2024Enrolled18ConditionsDialysis, Complications, Performance Enhancing Product UseArmsCreatine
NCT07377500 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Randomised Controlled Trial of Dialysate Cooling for the Preservation of Cognitive Function in People Receiving Haemodialysis

TypeinterventionalSponsorUniversity Hospitals of Derby and Burton NHS Foundation TrustRan2026 to 2028Enrolled356ConditionsHaemodialysis, Kidney FailureArmsDialysis cooling
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Epidemiology of peritoneal dialysis outcomes.Nature reviews. Nephrology · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Functional independence, access to kidney transplantation and waitlist mortality.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Article
  16. Article
  17. Article
  18. Decline in the Functional Status and Mortality in Patients on Hemodialysis: Results from the Japan Dialysis Outcome and Practice Patterns Study.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Niall T KavanaghGeriatric Research and Education Clinical Center, Palo Alto VA Health Care System, Palo Alto, California, USA.
Brigitte SchillerDivision of Nephrology, Stanford University School of Medicine, Palo Alto, California, USA.
Anjali B SaxenaDivision of Nephrology, Stanford University School of Medicine, Palo Alto, California, USA.
I-Chun ThomasGeriatric Research and Education Clinical Center, Palo Alto VA Health Care System, Palo Alto, California, USA.
Manjula Kurella TamuraGeriatric Research and Education Clinical Center, Palo Alto VA Health Care System, Palo Alto, California, USA.

Funding

MIND the KidneysR01DK092241 · NIDDK · STANFORD UNIVERSITY · PI KURELLA TAMURA, MANJULA · 2012 to 2016
$2.8M
Mechanisms of Cognitive Impairment in Chronic Kidney DiseaseK23AG028952 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURELLA TAMURA, MANJULA · 2007 to 2011
$860k
NIA NIH HHS K23 AG028952NIA NIH HHS K23AG028952NIDDK NIH HHS R01 DK092241NIDDK NIH HHS R01DK092241
6 · The paper itself

Abstract

Functional dependence is an important determinant of longevity and quality of life. The purpose of the current study was to determine the prevalence and correlates of functional dependence among patients with end-stage renal disease (ESRD) receiving maintenance dialysis. We enrolled 148 participants with ESRD from five clinics. Functional status, as measured by basic and instrumental activities of daily living (ADL, IADL), was ascertained by validated questionnaires. Functional dependence was defined as needing assistance in at least one of seven IADLs or at least one of four ADLs. Demographic characteristics, chronic health conditions, anthropometric measurements, and laboratories were assessed by a combination of self-report and chart review. Cognitive function was assessed with a neurocognitive battery, and depressive symptoms were assessed by questionnaire. Mean age of the sample was 56.2 ± 14.6 years. Eighty-seven participants (58.8%) demonstrated dependence in ADLs or IADLs, 70 (47.2%) exhibited IADL dependence alone, and 17 (11.5%) exhibited combined IADL and ADL dependence. In a multivariable-adjusted model, stroke, cognitive impairment, and higher systolic blood pressure were independent correlates of functional dependence. We found no significant association between demographic characteristics, chronic health conditions, depressive symptoms or laboratory measurements, and functional dependence. Impairment in executive function was more strongly associated with functional dependence than memory impairment. Functional dependence is common among ESRD patients and independently associated with stroke, systolic blood pressure, and executive function impairment.

Indexed as

Activities of Daily LivingAgedFemaleHumansKidney Failure, ChronicMaleMiddle AgedPrevalenceQuality of LifeRenal Dialysiscognitive impairmentdialysisESRDFunctional dependence

Identifiers

PMID25731070
PMCPMC7781228

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.