ArticleProceedings of the National Academy of Sciences of the United States of America2015
Cells as liquid motors: mechanosensitivity emerges from collective dynamics of actomyosin cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Microhand Platform Equipped with Plate-Shaped End-Effectors Enables Precise Probing of Intracellular Structure Contribution to Whole-Cell Mechanical Properties.Micromachines · 2025Article
- Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Supracellular actomyosin assemblies: master coordinators of development.Development (Cambridge, England) · 2025Review
- Sustained strain applied at high rates drives dynamic tensioning in epithelial cells.Communications biology · 2025Article
- Sustained Strain Applied at High Rates Drives Dynamic Tensioning in Epithelial Cells.bioRxiv : the preprint server for biology · 2025Article
- Atlasprofilax: a new promising treatment for chronic cervicobrachialgia. A qualitative-quantitative research of a retrospective longitudinal section, with a cause-effect approach.Frontiers in medical technology · 2025Article
- Regulation of intercellular viscosity by E-cadherin-dependent phosphorylation of EGFR in collective cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Active viscoelastic models for cell and tissue mechanics.Royal Society open science · 2024Article
- How dynamic prestress governs the shape of living systems, from the subcellular to tissue scale.Interface focus · 2022Review
- Lymph node homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics.Nature immunology · 2022Article
- Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation.Nature communications · 2022Article
- Durotaxis: the mechanical control of directed cell migration.The FEBS journal · 2022Review
- Adhesion-regulated junction slippage controls cell intercalation dynamics in an Apposed-Cortex Adhesion Model.PLoS computational biology · 2022Article
- Rapid viscoelastic changes are a hallmark of early leukocyte activation.Biophysical journal · 2021Article
- Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics.Frontiers in cell and developmental biology · 2021Review
- Substrate Resistance to Traction Forces Controls Fibroblast Polarization.Biophysical journal · 2020Article
- Self-organized cytoskeletal alignment duringPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Stiffness Sensing by Cells.Physiological reviews · 2020Review
- Actomyosin controls planarity and folding of epithelia in response to compression.Nature materials · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Living cells adapt and respond actively to the mechanical properties of their environment. In addition to biochemical mechanotransduction, evidence exists for a myosin-dependent purely mechanical sensitivity to the stiffness of the surroundings at the scale of the whole cell. Using a minimal model of the dynamics of actomyosin cortex, we show that the interplay of myosin power strokes with the rapidly remodeling actin network results in a regulation of force and cell shape that adapts to the stiffness of the environment. Instantaneous changes of the environment stiffness are found to trigger an intrinsic mechanical response of the actomyosin cortex. Cortical retrograde flow resulting from actin polymerization at the edges is shown to be modulated by the stress resulting from myosin contractility, which in turn, regulates the cell length in a force-dependent manner. The model describes the maximum force that cells can exert and the maximum speed at which they can contract, which are measured experimentally. These limiting cases are found to be associated with energy dissipation phenomena, which are of the same nature as those taking place during the contraction of a whole muscle. This similarity explains the fact that single nonmuscle cell and whole-muscle contraction both follow a Hill-like force-velocity relationship.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.