Trial reportProceedings of the National Academy of Sciences of the United States of America2015
Redefining the role of Broca's area in speech.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 237 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
237 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Embodying Time in the Brain: A Multi-Dimensional Neuroimaging Meta-Analysis of 95 Duration Processing Studies.Neuropsychology review · 2024Pooled it
- Large-scale Meta-analysis Suggests Low Regional Modularity in Lateral Frontal Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2018Pooled it
- Innovative strategies for managing hallucinations by exploring effects of tDCS on source monitoring abilities.Scientific reports · 2024Trial
- Trial
- Trial
- Language reorganization in brain arteriovenous malformations with fiber-based regional functional connectivity.Magnetic resonance letters · 2027Article
- Whole-brain millisecond-scale effective connectivity of auditory and visual naming.NeuroImage · 2026Article
- Differential roles of frontoparietal regions in working memory and decision-making.bioRxiv : the preprint server for biology · 2026Article
- Broca's area, responsible for speech production, is regulated by lung function.Neural regeneration research · 2026Article
- Brain-AI convergence: Generative world models and hierarchical attention for human intelligence.Patterns (New York, N.Y.) · 2026Review
- Electrocorticography During Deep Brain Stimulation Surgery for Movement Disorders: Single-Center Experience.Brain sciences · 2026Article
- Opposing effects of slow and fast theta synchrony on working memory in the human hippocampal-orbitofrontal network.bioRxiv : the preprint server for biology · 2026Article
- Prenatal Volume in the Bilateral Superior Temporal Gyrus Associates With Children's Expressive Vocabulary at 24-36 Months.Developmental science · 2026Article
- Stimulus-driven and behavior-driving activity along the cortical auditory hierarchy.NeuroImage · 2026Article
- Neural activity flows through cortical subnetworks during speech production.Cell reports · 2026Article
- Mapping the Cross-species Brain Connectivity Atlas and Hemispheric Asymmetry of the Temporal Pole in Humans and Macaques.Neuroscience bulletin · 2026Article
- The neural bases of frontotemporal dementia and primary progressive aphasia subtypes: insights from activation likelihood estimation meta-analyses of 8057 patients.Brain communications · 2026Review
- Reviewing vascular influences on neuronal migration, cortical development, and neurodevelopmental disorders: focus on autism, ADHD and schizophrenia.Molecular psychiatry · 2025Review
- Posterior Cortical Atrophy: Altered Language Processing System Connectivity and Its Implications on Language Comprehension and Production.Brain sciences · 2025Article
- Episodic memory involves transient and sparse connectivity aligned to both internal and external events.PLoS biology · 2025Article
177 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
For over a century neuroscientists have debated the dynamics by which human cortical language networks allow words to be spoken. Although it is widely accepted that Broca's area in the left inferior frontal gyrus plays an important role in this process, it was not possible, until recently, to detail the timing of its recruitment relative to other language areas, nor how it interacts with these areas during word production. Using direct cortical surface recordings in neurosurgical patients, we studied the evolution of activity in cortical neuronal populations, as well as the Granger causal interactions between them. We found that, during the cued production of words, a temporal cascade of neural activity proceeds from sensory representations of words in temporal cortex to their corresponding articulatory gestures in motor cortex. Broca's area mediates this cascade through reciprocal interactions with temporal and frontal motor regions. Contrary to classic notions of the role of Broca's area in speech, while motor cortex is activated during spoken responses, Broca's area is surprisingly silent. Moreover, when novel strings of articulatory gestures must be produced in response to nonword stimuli, neural activity is enhanced in Broca's area, but not in motor cortex. These unique data provide evidence that Broca's area coordinates the transformation of information across large-scale cortical networks involved in spoken word production. In this role, Broca's area formulates an appropriate articulatory code to be implemented by motor cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.