ArticleNature genetics2015
The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families.
Article in Nature genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Zoonotic Ancylostomiasis: An Update of a Continually Neglected Zoonosis.The American journal of tropical medicine and hygiene · 2020Pooled it
- FMRFamide-like peptides expand the behavioral repertoire of a densely connected nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2017Pooled it
- Transgenic hookworm secretes anti-tetrodotoxin human single chain antibody.Nature communications · 2026Article
- Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system.PLoS neglected tropical diseases · 2026Article
- Hookworm genomic diversity and population structure from accessible sample types: A validated approach to generate genome-wide polymorphism datasets from individual third-stage larvae.bioRxiv : the preprint server for biology · 2026Article
- An Argonaute protein traffics from nematode to mouse and is a vaccine against parasitic nematodes.EMBO reports · 2026Article
- Catalytically Active Recombinant Cysteine Proteases ofInternational journal of molecular sciences · 2025Article
- The Canine HookwormPathogens (Basel, Switzerland) · 2025Article
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- Chromosome-ContiguousInternational journal of molecular sciences · 2025Article
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- The parasitic nematode Strongyloides ratti exists predominantly as populations of long-lived asexual lineages.Nature communications · 2023Article
- Phylogenomic Analysis of 155 Helminth Species Reveals Widespread Absence of Oxygen Metabolic Capacity.Genome biology and evolution · 2023Article
- Excretory/Secretory Proteome of Females and Males of the HookwormPathogens (Basel, Switzerland) · 2023Article
- The improved genome of the nematode Parapristionchus giblindavisi provides insights into lineage-specific gene family evolution.G3 (Bethesda, Md.) · 2022Article
- A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus.Science advances · 2022Article
- Genome of the Giant Panda Roundworm Illuminates Its Host Shift and Parasitic Adaptation.Genomics, proteomics & bioinformatics · 2022Article
- A transcription factor DAF-5 functions in Haemonchus contortus development.Parasites & vectors · 2021Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Hookworms infect over 400 million people, stunting and impoverishing them. Sequencing hookworm genomes and finding which genes they express during infection should help in devising new drugs or vaccines against hookworms. Unlike other hookworms, Ancylostoma ceylanicum infects both humans and other mammals, providing a laboratory model for hookworm disease. We determined an A. ceylanicum genome sequence of 313 Mb, with transcriptomic data throughout infection showing expression of 30,738 genes. Approximately 900 genes were upregulated during early infection in vivo, including ASPRs, a cryptic subfamily of activation-associated secreted proteins (ASPs). Genes downregulated during early infection included ion channels and G protein-coupled receptors; this downregulation was observed in both parasitic and free-living nematodes. Later, at the onset of heavy blood feeding, C-lectin genes were upregulated along with genes for secreted clade V proteins (SCVPs), encoding a previously undescribed protein family. These findings provide new drug and vaccine targets and should help elucidate hookworm pathogenesis.
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