ArticleNeuropsychology2015
Increased neurocognitive intra-individual variability is associated with declines in medication adherence in HIV-infected adults.
Article in Neuropsychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of medication non-adherence in persons with dementia or cognitive impairment.PloS one · 2017Pooled it
- Exploring the potential of cognitive intra-individual variability in HIV care and research in adults with HIV: a concept analysis.Applied neuropsychology. Adult · 2026Review
- Difficulty with taking medications and the future risk of Alzheimer's disease and related dementias: Health and Retirement Study of Americans.American journal of neurodegenerative disease · 2026Article
- Does cognitive intra-individual variability predict change in everyday functioning performance in women with and without HIV in the Women's Interagency HIV Study?Applied neuropsychology. Adult · 2024Article
- Self-perceived cognitive fluctuations and their relationship to everyday functioning in older adults with and without HIV disease.The Clinical neuropsychologist · 2024Article
- Cognitive Intra-Individual Variability as an Outcome or Moderator of Speed of Processing Training in Aging Adults with HIV-Associated Neurocognitive Disorder: A Secondary Data Analysis of a 2-Year Longitudinal Randomized Clinical Trial.Archives of gerontology and geriatrics plus · 2024Article
- Lower prospective memory is associated with higher neurocognitive dispersion in two samples of people with HIV: A conceptual replication study.Journal of the International Neuropsychological Society : JINS · 2023Article
- Low incidence of advanced neurological burden but high incidence of age-related conditions that are dementia risk factors in aging people living with HIV: a data-linkage 10-year follow-up study.Journal of neurovirology · 2023Article
- Moving intra-individual variability (IIV) towards clinical utility: IIV measured using a commercial testing platform.Journal of the neurological sciences · 2023Article
- Cognitive Intra-individual Variability in HIV: an Integrative Review.Neuropsychology review · 2022Review
- Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice.Brain, behavior, & immunity - health · 2022Article
- Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV.Neurobiology of disease · 2022Article
- Conceptualizing and Assessing Everyday Functioning in the Context of HIV-Associated Neurocognitive Disorders.Current topics in behavioral neurosciences · 2021Review
- Enhancing cue salience improves aspects of naturalistic time-based prospective memory in older adults with HIV disease.Neuropsychology · 2021Article
- The Role of Mental Health Conditions in the Diagnosis of Neurocognitive Impairment in People Living with HIV.Diagnostics (Basel, Switzerland) · 2020Article
- Neurocognitive intra-individual variability within HIV+ adults with and without current substance use.Neuropsychology · 2020Article
- HIV, Depression, and Cognitive Impairment in the Era of Effective Antiretroviral Therapy.Current HIV/AIDS reports · 2019Review
- Article
- Intraindividual variability in neurocognitive performance: No influence due to HIV status or self-reported effort.Journal of clinical and experimental neuropsychology · 2018Article
- Intraindividual variability in neuropsychological performance predicts cognitive decline and death in HIV.Neuropsychology · 2018Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveThere is cross-sectional evidence that neurocognitive intra-individual variability (IIV), or dispersion, is elevated in human immunodeficiency virus (HIV) disease and is associated with declines in activities of daily living, including medication adherence.
methodsThis longitudinal study extends this literature by examining whether increased neurocognitive IIV in HIV-positive persons over time predicts declines in medication adherence above and beyond changes in mean level of performance over a 6-month observation.
resultsAfter controlling for drug use, declines in mean performance, and changes in depressive symptoms, results confirmed that increases in IIV were associated with overall poorer antiretroviral medication adherence. HIV-positive individuals with the greatest increases in dispersion demonstrated marked reductions in adherence by the third month that exceeded what was observed in less variable individuals.
conclusionsOur results indicate that increases in dispersion are associated with poorer declines in medication adherence in HIV disease, which may have implications for the early detection and remediation of suboptimal antiretroviral adherence.
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