Evidence map›Paper›PMID 25730728›Full record

ReviewNatural product reports2015

The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery.

Paul R Jensen, Bradley S Moore, William Fenical

Abstract readReview
In one paragraph

Review in Natural product reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Taxonomic and biosynthetic diversity of the marine actinomyceteApplied and environmental microbiology · 2026
    Article
  5. Article
  6. Nonradical Reactions ofThe Journal of organic chemistry · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Microbial genomics · 2024
    Article
  20. Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Paul R JensenCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, USA. pjensen@ucsd.edu.
Bradley S Moore
William Fenical

Funding

Exploration, conservation, & development of marine biodiversity in FijiU01TW007401 · FIC · GEORGIA INSTITUTE OF TECHNOLOGY · PI HAY, MARK E · 2005 to 2013
$7.4M
Natural Product Genome MiningR01GM085770 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JENSEN, PAUL R, MOORE, BRADLEY S · 2009 to 2024
$5.8M
The USP Center for Drug Discovery and ConservationU19TW007401 · FIC · GEORGIA INSTITUTE OF TECHNOLOGY · PI HAY, MARK E · 2014 to 2018
$5.3M
Antitumor-Antibiotics from Marine MicroorganismsR37CA044848 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FENICAL, WILLIAM · 2004 to 2013
$3.9M
Salinosporamide Biosynthesis and EngineeringR01CA127622 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOORE, BRADLEY S · 2007 to 2016
$2.8M
FIC NIH HHS U01 TW0007401FIC NIH HHS U01 TW007401FIC NIH HHS U19 TW007401NCI NIH HHS R01 CA127622NCI NIH HHS R01CA127622NCI NIH HHS R37 CA044848NIGMS NIH HHS R01 GM085770NIGMS NIH HHS R01GM085770
6 · The paper itself

Abstract

This review covers the initial discovery of the marine actinomycete genus Salinispora through its development as a model for natural product research. A focus is placed on the novel chemical structures reported with reference to their biological activities and the synthetic and biosynthetic studies they have inspired. The time line of discoveries progresses from more traditional bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target the products of specific biosynthetic gene clusters. This overview exemplifies the extraordinary biosynthetic diversity that can emanate from a narrowly defined genus and supports future efforts to explore marine taxa in the search for novel natural products.

Indexed as

ActinobacteriaBiological ProductsMarine BiologyModels, BiologicalMolecular StructureMultigene FamilyBiological Products

Identifiers

PMID25730728
PMCPMC4414829

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.