ArticleProceedings of the National Academy of Sciences of the United States of America1989
Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 90 citations in OpenAlex.
- Transcriptional networks driving enhancer function in the CFTR gene.The Biochemical journal · 2012Article
- Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells.Oncogene · 2010Article
- Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.The EMBO journal · 2005Article
- The HOX homeodomain proteins block CBP histone acetyltransferase activity.Molecular and cellular biology · 2001Article
- Article
- Review
- Sequence analysis and tissue specific expression of human HOXA7.Molecular biotechnology · 2000Article
- CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein.Oncogene · 1999Article
- HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium.The Journal of clinical investigation · 1998Article
- AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.Molecular and cellular biology · 1997Article
- Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.Nucleic acids research · 1996Article
- Identification of homeobox genes expressed during the process of rat liver regeneration after partial hepatectomy.Biochemical genetics · 1996Article
- Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells.Nucleic acids research · 1992Article
- Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines.The EMBO journal · 1992Article
- Coordinate regulation of HOX genes in human hematopoietic cells.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells.Nucleic acids research · 1991Article
- Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues.Nucleic acids research · 1991Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
We investigated the role of homeobox-containing genes in human hematopoiesis because homeobox genes (i) control cell fate in the Drosophila embryo, (ii) are expressed in specific patterns in human embryos, and (iii) appear to function as transcription factors that control cell phenotype in other mammalian organs. Using four homeobox probes from the HOX2 locus and a previously undescribed homeobox cDNA (PL1), we screened mRNAs from 18 human leukemic cell lines representing erythroid, myeloid, and T- and B-cell lineages. Complex patterns of lineage-restricted expression are observed: some are restricted to a single lineage, while others are expressed in multiple lineages. No single homeobox gene is expressed in all types of hematopoietic cells, but each cell type exhibits homeobox gene expression. HOX2.2 and -2.3 homeobox-containing cDNAs were cloned from an erythroleukemia cell (HEL) cDNA library, while the homeobox cDNA PL1 was isolated from a monocytic cell (U-937) library. Differentiation of HEL and K-562 cells with various inducers results in modulation of specific homeobox transcripts. In addition, HOX2.2 is expressed in normal bone marrow cells. We have demonstrated (i) lineage-restricted expression of five homeobox genes in erythroid and monocytic cell lines; (ii) expression of additional homeobox genes in other cell lineages (HL-60 and lymphoid cells); (iii) expression of one homeobox gene in normal marrow cells; and (iv) modulation of expression during differentiation. These data suggest that these genes play a role in human hematopoietic development and lineage commitment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.