ArticleObstetrics and gynecology2015
Risk of fetal death with preeclampsia.
Article in Obstetrics and gynecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Prevalence and materno-fetal outcomes of preeclampsia/eclampsia among pregnant women in Nigeria: a systematic review and meta-analysis.European journal of medical research · 2024Pooled it
- Association Between Preeclampsia and Blood Pressure in Offspring: A Systematic Review and Meta-Analysis.Current hypertension reports · 2024Pooled it
- SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.American journal of obstetrics and gynecology · 2022Pooled it
- What do we know about redox status? A review in neonates of mothers with preeclampsia.Annals of medicine · 2026Review
- Investigating the associations between prepregnancy lipoprotein(a) and birth outcomes: The Hispanic Community Health Study/Study of Latinos.Journal of clinical lipidology · 2026Article
- Improved risk stratification for placenta-mediated complications through the use of mid-gestational uterine artery Doppler: A retrospective cohort study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress-induced cellular senescence.FEBS open bio · 2026Article
- Protein C Levels in Human Immunodeficiency Virus-Infected Women with and Without Pre-Eclampsia in South Africa.Biomedicines · 2026Article
- 2D Shear Wave Elastography: An Evolving Technique for Comparison of Placental Elasticity in Normal and Preeclamptic Pregnancy.The Indian journal of radiology & imaging · 2026Article
- Healthy Live Births as Censoring Versus Competing Events in Studies of Prenatal Medication Use.Paediatric and perinatal epidemiology · 2026Article
- Bidirectional Associations Between Frailty and Preeclampsia: A Two-Sample Mendelian Randomization Study.International journal of women's health · 2026Article
- Isolated Proteinuria in Uncomplicated Twin Pregnancies vs. Singleton Pregnancies; Measured by Spot Protein-Creatinine Ratio.Journal of pregnancy · 2026Article
- The Etiopathogenesis of Preeclampsia: Where Do We Stand Now?Journal of clinical medicine · 2025Review
- Magnitude and determinants of adverse perinatal outcomes of pregnancies complicated with preeclampsia and eclampsia at a teaching hospital in the Tigray region of Ethiopia.Scientific reports · 2025Article
- Risk factors associated with progression from pre-eclampsia to eclampsia: A prospective cohort study and population-wide data analysis.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Association of placental manganese levels, maternal gut microbiota, and preeclampsia: a tripartite perspective.Frontiers in microbiology · 2025Article
- Using machine learning to predict the risk of developing hypertensive disorders of pregnancy using a contemporary nulliparous cohort.AJOG global reports · 2024Article
- Article
- Dual Tragedy of Fetal and Maternal Loss: A Case of Acute Liver Failure in the Third Trimester.Cureus · 2024Article
- The Association of Hypertensive Disorders of Pregnancy with Infant Mortality, Preterm Delivery, and Small for Gestational Age.Healthcare (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo estimate gestational age-specific risks of fetal death in pregnancies complicated by preeclampsia.
methodsPopulation-based cohort study comprising all singleton births (N=554,333) without preexisting chronic hypertension recorded in the Norwegian Medical Birth Registry from 1999 to 2008. Additional data come from a subset of preeclamptic pregnancies enrolled in the Norwegian Mother and Child Cohort Study with available medical records (n=3,037). The risk of fetal death, expressed per 1,000 fetuses exposed to preeclampsia, was calculated using a life table approach.
resultsPreeclampsia was recorded in 3.8% (n=21,020) of all pregnancies. Risk of stillbirth was 3.6 per 1,000 overall and 5.2 per 1,000 among pregnancies with preeclampsia (relative risk 1.45, 95% confidence interval [CI] 1.20-1.76). However, relative risk of stillbirth was markedly elevated with preeclampsia in early pregnancy. At 26 weeks of gestation, there were 11.6 stillbirths per 1,000 pregnancies with preeclampsia compared with 0.1 stillbirths per 1,000 pregnancies without (relative risk 86, 95% CI 46-142). Fetal risk with preeclampsia declined as pregnancy advanced, but at 34 weeks of gestation remained more than sevenfold higher than pregnancies without preeclampsia.
conclusionFor clinical purposes, the fetal risk of death associated with preeclampsia begins when preeclampsia becomes clinically apparent. Using a method that takes into account the clinical diagnosis of preeclampsia and the population of fetuses at risk, we find a remarkably high relative risk of fetal death among pregnancies diagnosed with preeclampsia in the preterm period. LEVEL OF EVIDENCE: II.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.