ArticleFrontiers in immunology2015
ATP-Induced IL-1β Specific Secretion: True Under Stringent Conditions.
Article in Frontiers in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- Protein Kinase C δ: a critical hub regulating macrophage immunomodulatory functions duringbioRxiv : the preprint server for biology · 2025Article
- Prevention of M2 polarization and temporal limitation of differentiation in monocytes by extracellular ATP.BMC immunology · 2023Article
- Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling.Frontiers in immunology · 2023Review
- Platelet-Rich Fibrin Reduces IL-1β Release from Macrophages Undergoing Pyroptosis.International journal of molecular sciences · 2022Article
- A selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington's disease.Journal of neuroinflammation · 2022Article
- Macrophage/microglia-derived IL-1β induces glioblastoma growth via the STAT3/NF-κB pathway.Human cell · 2022Article
- Article
- Inflammatory responses to metal oxide ceramic nanopowders.Scientific reports · 2021Article
- SIRT1 and SIRT2 modulators reduce LPS-induced inflammation in HAPI microglial cells and protect SH-SY5Y neuronal cells in vitro.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Anti-Inflammatory Effect Fraction ofMediators of inflammation · 2021Article
- Varenicline Prevents LPS-Induced Inflammatory Response via Nicotinic Acetylcholine Receptors in RAW 264.7 Macrophages.Frontiers in molecular biosciences · 2021Article
- Commensal Microbiome Expands Tγδ17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia.Frontiers in immunology · 2021Article
- An allosteric interleukin-1 receptor modulator mitigates inflammation and photoreceptor toxicity in a model of retinal degeneration.Journal of neuroinflammation · 2020Article
- Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Association between P2X7 Polymorphisms and Post-Transplant Outcomes in Allogeneic Haematopoietic Stem Cell Transplantation.International journal of molecular sciences · 2020Article
- Peripheral Inflammatory Hyperalgesia Depends on P2X7 Receptors in Satellite Glial Cells.Frontiers in physiology · 2020Article
- Coelonin, an Anti-Inflammation Active Component ofInternational journal of molecular sciences · 2019Article
- Kinetics of MSC-based enzyme therapy for immunoregulation.Journal of translational medicine · 2019Article
- The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.The Journal of biological chemistry · 2019Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-1β is a potent proinflammatory cytokine, of which processing and secretion are tightly regulated. After exposure to various stimuli, mononuclear phagocytes synthesize the inactive precursor (pro-IL-1β), which is then cleaved intracellularly by caspase-1 and secreted. A widely used method for in vitro secretion of IL-1β employs LPS-primed human peripheral blood monocytes. Subsequently, adenosine triphosphate (ATP) is added to the cells in order to trigger the P2X7 receptor resulting in processing and secretion of mature IL-1β. However, it is often reported that secretion is due to cytotoxic effects of ATP with P2X7 receptor-activation-related cell death. We have challenged this concept and demonstrate IL-1β specific secretion, since there is no increase in cell death and IL-1α and IL-18 are not released in the same cultures. More importantly we show that these conclusions can only be drawn under stringent experimental conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.