ArticleFrontiers in neurology2015
Fatigue in multiple sclerosis: a look at the role of poor sleep.
Article in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- The prevalence of obstructive sleep apnea-hypopnea syndrome in patients with multiple sclerosis: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Efficacy of diet on fatigue, quality of life and disability status in multiple sclerosis patients: rapid review and meta-analysis of randomized controlled trials.BMC neurology · 2022Pooled it
- Trial
- Sleep Hygiene and Symptom Burden in Multiple Sclerosis: A Cross-Sectional Study.Clocks & sleep · 2026Article
- Sleep disorders in patients with multiple sclerosis.BMC neurology · 2025Article
- Frequency and risk factors of sleep problems in Egyptian patients with multiple sclerosis.Frontiers in neurology · 2025Article
- The association of comorbidities with sleep quality among Australians with multiple sclerosis: Insights from the Australian Multiple Sclerosis Longitudinal Study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Renshen Yangrong decoction for secondary malaise and fatigue: network pharmacology and Mendelian randomization study.Frontiers in nutrition · 2024Article
- Article
- The Big Five Personality Traits and Positive Orientation in Polish Adults with Multiple Sclerosis: The Role of Meaning in Life.International journal of environmental research and public health · 2022Article
- Demographic, clinical, and symptomatic correlates of subjective sleep quality in adults with multiple sclerosis.Multiple sclerosis and related disorders · 2021Article
- Predictors of sleep quality among university students: the use of advanced machine learning techniques.Sleep & breathing = Schlaf & Atmung · 2021Article
- Contribution of sleep quality to fatigue following a stroke: a cross-sectional study.BMC neurology · 2021Article
- Sleep Disturbances Associated with Neurological Autoimmunity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Therapeutic Approaches to Insomnia and Fatigue in Patients with Multiple Sclerosis.Nature and science of sleep · 2021Review
- Article
- Better Objective Sleep Was Associated with Better Subjective Sleep and Physical Activity; Results from an Exploratory Study under Naturalistic Conditions among Persons with Multiple Sclerosis.International journal of environmental research and public health · 2020Article
- Impact of depression and fatigue on relapsing remitting multiple sclerosis in Kingdom of Saudi Arabia.Saudi medical journal · 2020Article
- Non-restorative Sleep Caused by Autonomic and Electroencephalography Parameter Dysfunction Leads to Subjective Fatigue at Wake Time in Shift Workers.Frontiers in neurology · 2019Article
- A protocol for a randomised double-blind placebo-controlled feasibility study to determine whether the daily consumption of flavonoid-rich pure cocoa has the potential to reduce fatigue in people with relapsing and remitting multiple sclerosis (RRMS).Pilot and feasibility studies · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue is a frequent and debilitating symptom of multiple sclerosis (MS) with rates ranging anywhere from 53 to 90%. Despite its high prevalence and grave impact on overall functioning and quality of life, the accurate definition, quantification, and etiology of fatigue have plagued the MS literature and clinical care for decades. With regard to its etiology, MS-related fatigue has been construed as being either primary or secondary. Primary fatigue is purported to be related to centrally mediated processes of the disease whereas secondary fatigue is thought to be a result of the host of factors that may accompany MS (e.g., depression, sleep disturbance). The present paper focuses on secondary fatigue and the role of sleep disturbance, in particular. Despite the intuitive assumption that sleep problems could contribute to fatigue, sleep problems in MS have gone fairly unrecognized until recently. The present paper provides a brief review of the literature pertaining to the prevalence and nature of sleep problems in MS as well as their association with fatigue. A replication of this author's and others work is presented further demonstrating that sleep disturbance is a significant contributor to fatigue in MS when taking into account disease variables, depression, and sleep disturbance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.