ArticleFrontiers in neural circuits2015
Characterizing synaptic protein development in human visual cortex enables alignment of synaptic age with rat visual cortex.
Article in Frontiers in neural circuits, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Amblyopia: progress and promise of functional magnetic resonance imaging.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Pooled it
- Anatomical and molecular development of the human primary visual cortex.Frontiers in cellular neuroscience · 2024Review
- Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Corrigendum: A Practical Guide to SparseFrontiers in neuroscience · 2022Article
- Longtime Vision Function Prediction in Childhood Cataract Patients Based on Optical Coherence Tomography Images.Frontiers in bioengineering and biotechnology · 2021Article
- A Practical Guide to SparseFrontiers in neuroscience · 2021Article
- Evaluation of cochlear activity in normal-hearing musicians.Hearing research · 2020Article
- The development of pain circuits and unique effects of neonatal injury.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- A Primer on Constructing Plasticity Phenotypes to Classify Experience-Dependent Development of the Visual Cortex.Frontiers in cellular neuroscience · 2020Article
- Experience-dependent development of visual sensitivity in larval zebrafish.Scientific reports · 2019Article
- Classification of Visual Cortex Plasticity Phenotypes following Treatment for Amblyopia.Neural plasticity · 2019Article
- The development of human visual cortex and clinical implications.Eye and brain · 2018Review
- A translational model to determine rodent's age from human foetal age.Scientific reports · 2017Article
- A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia.eLife · 2017Article
- Development of Glutamatergic Proteins in Human Visual Cortex across the Lifespan.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.Nature medicine · 2016Article
- Classic and Golli Myelin Basic Protein have distinct developmental trajectories in human visual cortex.Frontiers in neuroscience · 2015Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although many potential neuroplasticity based therapies have been developed in the lab, few have translated into established clinical treatments for human neurologic or neuropsychiatric diseases. Animal models, especially of the visual system, have shaped our understanding of neuroplasticity by characterizing the mechanisms that promote neural changes and defining timing of the sensitive period. The lack of knowledge about development of synaptic plasticity mechanisms in human cortex, and about alignment of synaptic age between animals and humans, has limited translation of neuroplasticity therapies. In this study, we quantified expression of a set of highly conserved pre- and post-synaptic proteins (Synapsin, Synaptophysin, PSD-95, Gephyrin) and found that synaptic development in human primary visual cortex (V1) continues into late childhood. Indeed, this is many years longer than suggested by neuroanatomical studies and points to a prolonged sensitive period for plasticity in human sensory cortex. In addition, during childhood we found waves of inter-individual variability that are different for the four proteins and include a stage during early development (<1 year) when only Gephyrin has high inter-individual variability. We also found that pre- and post-synaptic protein balances develop quickly, suggesting that maturation of certain synaptic functions happens within the 1 year or 2 of life. A multidimensional analysis (principle component analysis) showed that most of the variance was captured by the sum of the four synaptic proteins. We used that sum to compare development of human and rat visual cortex and identified a simple linear equation that provides robust alignment of synaptic age between humans and rats. Alignment of synaptic ages is important for age-appropriate targeting and effective translation of neuroplasticity therapies from the lab to the clinic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.