ArticleJournal of Korean medical science2015
Early sodium and fluid intake and severe intraventricular hemorrhage in extremely low birth weight infants.
Article in Journal of Korean medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Sodium supplementation strategies in preterm infants: effects on growth, electrolyte balance, and exploratory evidence on neurodevelopment - a systematic review and meta-analysis.BMC nutrition · 2026Pooled it
- Early Postnatal Weight Loss and Its Association with Outcomes in Very Preterm Neonates: A Systematic Review and Meta-Analysis.Neonatology · 2025Pooled it
- Higher versus lower sodium intake for preterm infants.The Cochrane database of systematic reviews · 2023Pooled it
- Association between fluid overload and mortality in newborns: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2022Pooled it
- Early fluid status and severe intraventricular hemorrhage or death in extremely preterm infants.Pediatric nephrology (Berlin, Germany) · 2026Article
- Sweet or Salty: Comparing Dextrose and Sodium Acetate Umbilical Arterial Catheter Fluids.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Sodium Values During the First 10 Postnatal Days in Extremely-Low-Birth-Weight Infants and Long-Term Neurocognitive Outcomes: A Systematic Review.Children (Basel, Switzerland) · 2026Review
- Hypernatremia during the first week of life in very preterm infants and neurodevelopmental outcomes at 3 to 4 years of age: a cohort study.BMC pediatrics · 2026Article
- Early glucose and sodium trajectories and short-term outcomes in extremely preterm infants.Frontiers in pediatrics · 2026Article
- Perinatal Neuroprotection in Preterm Birth.Geburtshilfe und Frauenheilkunde · 2025Article
- Third-day weight changes and bronchopulmonary dysplasia risk in preterm infants: a cohort study.Frontiers in pediatrics · 2025Article
- Thermoregulation, incubator humidity, and skincare practices in appropriate for gestational age ultra-low birth weight infants: need for more evidence.World journal of pediatrics : WJP · 2024Review
- Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series).Pediatric research · 2024Review
- Excessive sodium supplementation but not fluid load is correlated with overall morbidity in extremely low birth weight infants.JPGN reports · 2024Article
- New frontiers in neonatal red blood cell transfusion research.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Sodium supply from administered blood products was associated with severe intraventricular haemorrhage in extremely preterm infants.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study.Children (Basel, Switzerland) · 2022Article
- Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants.Frontiers in pediatrics · 2022Article
- Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- ELBW infants receive inadvertent sodium load above the recommended intake.Pediatric research · 2020Observational
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypernatremic dehydration is an important cause of intracranial hemorrhage. A possible association of intraventricular hemorrhage (IVH) with hypernatremia and/or high sodium intake has been suggested in preterm infants. To investigate the associations of early fluid and sodium intake or serum sodium concentrations with severe intraventricular hemorrhage (IVH) in extremely low birth weight (ELBW) infants, we reviewed the medical records of 169 inborn ELBW infants. Daily fluid and sodium intake, urine output, weight loss and serum sodium concentration during the first 4 days of life were obtained. Patients were divided into the severe IVH (grade 3/4) and the control (no or grade 1/2 IVH) group. The maximum serum sodium concentration and the incidence of hypernatremia did not differ between the two groups. Related to the fluid balance and sodium intake, the risk for severe IVH was strongly associated with total fluid and sodium intake during the initial four days of life. With respect to the fluids other than transfusion, severe IVH can be discriminated only by sodium intake but not by fluid intake. Large randomized controlled trials are required to clarify the causal relationship between the early sodium intake and severe IVH in ELBW infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.