ArticleJournal of Korean medical science2015
Environmental heavy metal exposure and chronic kidney disease in the general population.
Article in Journal of Korean medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 79 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 188 citations in OpenAlex.
- Toxic Metals and Chronic Kidney Disease: a Systematic Review of Recent Literature.Current environmental health reports · 2018Pooled it
- Urinary KIM-1: a novel biomarker for evaluation of occupational exposure to lead.Scientific reports · 2016Trial
- Investigation of Sr-doped ZnO electron transport layers for perovskite solar cells: a combined DFT and SCAPS-1D study.RSC advances · 2026Article
- Glycemic Regulation and Renal Function by Heavy Metal Exposure: A Cross-Sectional Analysis on Cement Plant Workers.Journal of applied toxicology : JAT · 2026Article
- Association Between Blood Heavy Metals and Selenium with All-Cause Mortality in Cardiovascular-Kidney-Metabolic Syndrome Populations: Exploring the Mediating Effects of Inflammatory Biomarkers.Cardiovascular toxicology · 2026Article
- Comprehensive sub-chronic toxicological profiling of illegal artisanal small-scale mining-polluted river bodies in four regions of Ghana.Toxicology reports · 2026Article
- Operation-specific and time-resolved monitoring of occupational nano/sub-micron particle exposure in a Swedish metal additive manufacturing facility.Annals of work exposures and health · 2026Article
- Review
- Article
- Mechanism for adverse renal effects from heavy metals exposure in the CRIC study.BMC nephrology · 2026Article
- Urinary heavy metal and trace element mixtures in chronic kidney disease: associations and implications for potential reverse causality.Frontiers in toxicology · 2026Article
- Cadmium Toxicity in Children and Its Detection Using Colorimetric and Fluorimetric Methods.Journal of fluorescence · 2025Review
- Relationship between Serum Cadmium Concentration and Lung Function: A Study Using Korea National Health and Nutrition Examination Survey Data.Tuberculosis and respiratory diseases · 2025Article
- Multiple metal exposure and renal tubular damage of residents in a metal-polluted region in Korea.Environmental analysis, health and toxicology · 2025Article
- Combined Effect of per- and Polyfluoroalkyl Substances, Toxic Metals, and Essential Elements on Chronic Kidney Disease.Pollutants · 2025Article
- Early Zinc Supplementation Enhances Epididymal Sperm Glycosylation, Endocrine Activity, and Antioxidant Activity in Rats Exposed to Cadmium.International journal of molecular sciences · 2025Article
- Association of whole blood heavy metal concentrations with kidney function.Scientific reports · 2025Article
- INFERRING SYNERGISTIC AND ANTAGONISTIC INTERACTIONS IN MIXTURES OF EXPOSURES.The annals of applied statistics · 2025Article
- Association between blood cadmium levels and the risk of chronic kidney disease in Korea, based on the Korea National Health and Nutrition Examination Survey 2016-2017.Asian biomedicine : research, reviews and news · 2025Article
- A Comparative Study on the Paradoxical Relationship Between Heavy Metal Exposure and Kidney Function.Diagnostics (Basel, Switzerland) · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedErratum: environmental heavy metal exposure and chronic kidney disease in the general population.2015 · Rhu, Seungho [corrected to Ryu, Seungho]
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lead (Pb), mercury (Hg), and cadmium (Cd) are common heavy metal toxins and cause toxicological renal effects at high levels, but the relevance of low-level environmental exposures in the general population is controversial. A total of 1,797 adults who participated in the KNHANES (a cross-sectional nationally representative survey in Korea) were examined, and 128 of them (7.1%) had chronic kidney disease (CKD). Our study assessed the association between Pb, Hg, Cd exposure, and CKD. Blood Pb and Cd levels were correlated with CKD in univariate logistic regression model. However, these environmental heavy metals were not associated with CKD after adjustment for age, sex, BMI, smoking, hyperlipidemia, hypertension, diabetes, and these metals in multivariate logistic regression models. We stratified the analysis according to hypertension or diabetes. In the adults with hypertension or diabetes, CKD had a significant association with elevated blood Cd after adjustment, but no association was present with blood Pb and Hg. The corresponding odds ratio [OR] of Cd for CKD were 1.52 (95% confidence interval [CI], 1.05-2.19, P=0.026) in adults with hypertension and 1.92 (95% CI, 1.14-3.25, P=0.014) in adults with diabetes. Environmental low level of Pb, Hg, Cd exposure in the general population was not associated with CKD. However, Cd exposure was associated with CKD, especially in adults with hypertension or diabetes. This finding suggests that environmental low Cd exposure may be a contributor to the risk of CKD in adults with hypertension or diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.