Evidence map›Paper›PMID 25728946›Full record

ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2015

Biology and mechano-response of tendon cells: Progress overview and perspectives.

Hui B Sun, Christoph Schaniel, Daniel J Leong, James H-C Wang

Open access · greenAbstract readReview
In one paragraph

Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Load transfer, damage, and failure in ligaments and tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Hui B SunDepartment of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York.
Christoph Schaniel
Daniel J Leong
James H-C Wang
Albert Einstein College of Medicine · USIcahn School of Medicine at Mount Sinai · USUniversity of Pittsburgh · US

Funding

Human tendon stem progenitor cell aging and regenerationR01AG039561 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FLATOW, EVAN L, SUN, HUI BIN · 2012 to 2016
$2.5M
Repair of tendinopathic tendonsR01AR061395 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JAMES H-C. · 2011 to 2015
$1.8M
The role of TSCs in the degenerative tendinopathy induced by mechanical loadingR01AR065949 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JAMES H-C. · 2015 to 2019
$1.7M
A tissue specific approach to enhance tendon repairR21AR060920 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JAMES H-C. · 2012 to 2013
$365k
NIAMS NIH HHS AR060920NIAMS NIH HHS AR061395NIAMS NIH HHS R01 AR061395NIAMS NIH HHS R01 AR065949NIAMS NIH HHS R21 AR060920NIA NIH HHS AG039561NIA NIH HHS R01 AG039561
6 · The paper itself

Abstract

In this review, we summarize the group discussions on Cell Biology & Mechanics from the 2014 ORS/ISMMS New Frontiers in Tendon Research Conference. The major discussion topics included: (1) the biology of tendon stem/progenitor cells (TSPCs) and the potential of stem cell-based tendon therapy using TSPCs and other types of stem cells, namely, embryonic and/or induced pluripotent stem cells (iPSCs), (2) the biological concept and potential impact of cellular senescence on tendon aging, tendon injury repair and the development of degenerative disease, and (3) the effects of tendon cells' mechano-response on tendon cell fate and metabolism. For each topic, a brief overview is presented which summarizes the major points discussed by the group participants. The focus of the discussions ranged from current research progress, challenges and opportunities, to future directions on these topics. In the preparation of this manuscript, authors consulted relevant references as a part of their efforts to present an accurate view on the topics discussed.

Indexed as

Mechanotransduction, CellularAnimalsCellular SenescenceHumansPluripotent Stem CellsRegenerationTendonsiPSCsmechanical loadingsenescencetendon degenerationTSPCs

Identifiers

PMID25728946
PMCPMC4422159
OpenAlexW1601933959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.