Evidence map›Paper›PMID 25728824›Full record

ArticleEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V2015

Evaluation of topical hesperetin matrix film for back-of-the-eye delivery.

Goutham R Adelli, Tushar Hingorani, Nagendra Punyamurthula, Sai Prachetan Balguri, Soumyajit Majumdar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Ocular Delivery of Polyphenols: Meeting the Unmet Needs.Molecules (Basel, Switzerland) · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Goutham R AdelliDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, MS, USA.
Tushar HingoraniDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, MS, USA.
Nagendra PunyamurthulaDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, MS, USA.
Sai Prachetan BalguriDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, MS, USA.
Soumyajit MajumdarDepartment of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, MS, USA; Research Institute of Pharmaceutical Sciences, The University of Mississippi, MS, USA; National Center for Natural Product Research, The University of Mississippi, MS, USA. Electronic address: majumso@olemiss.edu.
University of Mississippi · US

Funding

Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)P20GM104932 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2012 to 2016
$10.0M
NIGMS NIH HHS P20 GM104932NIGMS NIH HHS P20GM104932
6 · The paper itself

Abstract

purposeThe goal of the present study was to develop a poly (ethylene oxide) N10 (PEO N10) based melt-cast matrix system for efficient and prolonged delivery of hesperetin (HT), a promising bioflavonoid, to the posterior segment of the eye through the topical route.

methodsHT film was prepared by melt-cast method using PEO N10 and cut into 4mm×2mm segments, each weighing 8mg. This film was evaluated with respect to in vitro release rates and also transmembrane delivery across Spectra/Por® membrane (MWCO: 10,000 Daltons) and isolated rabbit corneas. Ocular tissue concentrations were also determined postapplication of the film in ex vivo and in vivo models.

resultsHT release from the film was determined to be about 95.3% within 2h. In vitro transcorneal flux was observed to be 0.58±0.05μg/min/cm(2) across the isolated rabbit cornea. High levels of HT were detected in the retina-choroid (RC) and vitreous humor (VH) in the ex vivo model following topical application of the film. Significant levels of HT were observed in both anterior and posterior segment ocular tissues 1h post topical application of the 10 and 20%w/w HT films on the rabbit eye. Moreover, HT was detected in the VH and RC even after 6h following topical application of the film in vivo.

conclusionThe results from this study suggest that the melt-cast films can serve as a viable platform for sustained topical delivery of bioflavonoids, and other therapeutic agents, into the back-of-the eye tissues.

Indexed as

Drug Delivery SystemsAdministration, TopicalAnimalsCorneaDrug CompoundingDrug LiberationEyeHesperidinMalePolyethylene GlycolsRabbitsTime FactorsTissue DistributionhesperetinHesperidinPolyethylene GlycolsBack-of-the eye deliveryBioflavonoidsHesperetinHot melt extrusionMelt-cast technologyPolyethylene oxidePolymeric matrix filmSustained deliveryTopical application

Identifiers

PMID25728824
PMCPMC4430415
OpenAlexW1999169692

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.