Evidence map›Paper›PMID 25728651›Full record

ReviewJournal of molecular biology2015

A proteomics perspective on viral DNA sensors in host defense and viral immune evasion mechanisms.

Marni S Crow, Aaron Javitt, Ileana M Cristea

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Diverse mechanisms evolved by DNA viruses to inhibit early host defenses.Critical reviews in biochemistry and molecular biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marni S CrowDepartment of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA.
Aaron JavittDepartment of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA.
Ileana M CristeaDepartment of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA. Electronic address: icristea@princeton.edu.
Princeton University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Mechanisms mediating immune response upon sensing of nuclear viral DNAR01GM114141 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 2015 to 2023
$2.6M
Functional investigation of the TBX20 cardiac interactomeR01HL127640 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CONLON, FRANK LEO, CRISTEA, ILEANA M. · 2015 to 2018
$2.5M
Direct and Quantitative Proteomic Approaches in XenopusR21HD073044 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CONLON, FRANK LEO, CRISTEA, ILEANA M. · 2013 to 2014
$436k
Host Factors Required for Dengue and Yellow Fever Virus AmplificationR21AI102187 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CRISTEA, ILEANA M., THOMPSON, SUNNIE R · 2012 to 2013
$414k
NHLBI NIH HHS R01 HL127640NIAID NIH HHS R21 AI102187NIAID NIH HHS R21AI102187NICHD NIH HHS R21 HD073044NICHD NIH HHS R21HD073044NIGMS NIH HHS R01 GM114141NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

The sensing of viral DNA is an essential step of cellular immune response to infections with DNA viruses. These human pathogens are spread worldwide, triggering a wide range of virus-induced diseases, and are associated with high levels of morbidity and mortality. Despite similarities between DNA molecules, mammalian cells have the remarkable ability to distinguish viral DNA from their own DNA. This detection is carried out by specialized antiviral proteins, called DNA sensors. These sensors bind to foreign DNA to activate downstream immune signaling pathways and alert neighboring cells by eliciting the expression of antiviral cytokines. The sensing of viral DNA was shown to occur both in the cytoplasm and in the nucleus of infected cells, disproving the notion that sensing occurred by simple spatial separation of viral and host DNA. A number of omic approaches, in particular, mass-spectrometry-based proteomic methods, have significantly contributed to the constantly evolving field of viral DNA sensing. Here, we review the impact of omic methods on the identification of viral DNA sensors, as well as on the characterization of mechanisms involved in host defense or viral immune evasion.

Indexed as

Immune EvasionAnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCytoplasmDNA, ViralHost-Pathogen InteractionsHumansMammalsMass SpectrometryNuclear ProteinsNucleotidyltransferasesPhosphoproteinsProtein Interaction MapsProteinsProteomicsSignal TransductioncGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA, ViralIFI16 protein, humanNuclear ProteinsNucleotidyltransferasesPhosphoproteinsProteinsIFI16immune responseproteomicsviral DNA sensingvirus–host interactions

Identifiers

PMID25728651
PMCPMC4669196
OpenAlexW1998319169

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.