Evidence map›Paper›PMID 25728618›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2015

Oestrogen hormone receptors in focal nodular hyperplasia.

Manju D Chandrasegaram, Ali Shah, John W Chen, Andrew Ruszkiewicz, David S Astill, Georgina England, Ravish S Raju, Eu Ling Neo, Paul M Dolan, Chuan Ping Tan and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Benign Liver Tumors.Visceral medicine · 2020
    Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Manju D ChandrasegaramHepatobiliary Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.
Ali ShahHepatobiliary Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.
John W ChenHepatobiliary Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.
Andrew RuszkiewiczDepartment of Tissue Pathology, SA Pathology, Royal Adelaide Hospital Site, Adelaide, SA, Australia.
David S AstillDepartment of Tissue Pathology, SA Pathology, Flinders Medical Centre Site, Adelaide, SA, Australia.
Georgina EnglandDepartment of Tissue Pathology, SA Pathology, Royal Adelaide Hospital Site, Adelaide, SA, Australia.
Ravish S RajuDepartment of Surgery, Flinders Medical Centre, Adelaide, SA, Australia.
Eu Ling NeoHepatobiliary Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.
Paul M DolanHepatobiliary Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.
Chuan Ping TanHepatobiliary Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.
Mark Brooke-SmithHepatobiliary Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.
Tom WilsonDepartment of Surgery, Flinders Medical Centre, Adelaide, SA, Australia.
Robert T A PadburyDepartment of Surgery, Flinders Medical Centre, Adelaide, SA, Australia.
Christopher S WorthleyHepatobiliary Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.
Royal Adelaide Hospital · AUFlinders Medical Centre · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of hormones in focal nodular hyperplasia (FNH) has been investigated with conflicting results.

objectiveThe aim of this study was to evaluate oestrogen and progesterone receptor immunohistochemical expression in FNH and surrounding normal liver (control material).

methodsBiopsy materials from FNH and control tissue were investigated using an immunostainer. Receptor expression was graded as the proportion score (percentage of nuclear staining) and oestrogen receptor intensity score.

resultsStudy material included tissue from 11 resected FNH lesions and two core biopsies in 13 patients (two male). Twelve samples showed oestrogen receptor expression. The percentage of nuclear oestrogen receptor staining was <33% in eight FNH biopsies, 34-66% in two FNH biopsies, and >67% in both core biopsies. The better staining in core biopsies relates to limitations of the staining technique imposed by the fibrous nature of larger resected FNH. Control samples from surrounding tissue were available for nine of the resected specimens and all showed oestrogen receptor expression. Progesterone receptor expression was negligible in FNH and control samples.

conclusionsBy contrast with previous studies, the majority of FNH and surrounding liver in this cohort demonstrated oestrogen receptor nuclear staining. The implications of this for continued oral contraceptive use in women of reproductive age with FNH remain uncertain given the lack of consistent reported growth response to oestrogen stimulation or withdrawal.

Indexed as

AdultBiopsyCell NucleusContraceptives, Oral, HormonalFemaleFocal Nodular HyperplasiaHepatectomyHumansImmunohistochemistryLiverMaleMiddle AgedPredictive Value of TestsReceptors, EstrogenReceptors, ProgesteroneContraceptives, Oral, HormonalReceptors, EstrogenReceptors, Progesterone

Identifiers

PMID25728618
PMCPMC4430780
OpenAlexW2056938055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.