ArticleScientific reports2015
Large-scale topographical screen for investigation of physical neural-guidance cues.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 102 citations in OpenAlex.
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- Constructive Neuroengineering of Crossing Multi-Neurite Wiring Using Modifiable Agarose Gel Platforms.Gels (Basel, Switzerland) · 2025Article
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- The Future of Biohybrid Regenerative Bioelectronics.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Nanomagnetic Guidance Shapes the Structure-Function Relationship of Developing Cortical Networks.Nano letters · 2024Article
- Electrophysiological features of cortical 3D networks are deeply modulated by scaffold properties.APL bioengineering · 2024Article
- Evolution of Retinal Neuron Fractality When Interfacing with Carbon Nanotube Electrodes.Bioengineering (Basel, Switzerland) · 2024Article
- Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Substrate topography affects PC12 cell differentiation through mechanotransduction mechanisms.Mechanobiology in medicine · 2024Article
- Fractal Resonance: Can Fractal Geometry Be Used to Optimize the Connectivity of Neurons to Artificial Implants?Advances in neurobiology · 2024Article
- Plant Cellulose as a Substrate for 3D Neural Stem Cell Culture.Bioengineering (Basel, Switzerland) · 2023Article
- Sensitivity of CNN image analysis to multifaceted measurements of neurite growth.BMC bioinformatics · 2023Article
- High-Performance Implantable Sensors based on Anisotropic Magnetoresistive LaACS biomaterials science & engineering · 2023Article
- Submicron Topographically Patterned 3D Substrates Enhance Directional Axon Outgrowth of Dorsal Root Ganglia Cultured Ex Vivo.Biomolecules · 2022Article
- Insight and Recent Advances into the Role of Topography on the Cell Differentiation and Proliferation on Biopolymeric Surfaces.International journal of molecular sciences · 2022Review
- Regulatory Effects of Gradient Microtopographies on Synapse Formation and Neurite Growth in Hippocampal Neurons.Journal of micromechanics and microengineering : structures, devices, and systems · 2022Article
- Application and prospects of high-throughput screening forWorld journal of stem cells · 2022Review
- High-Content Screening and Analysis of Stem Cell-Derived Neural Interfaces Using a Combinatorial Nanotechnology and Machine Learning Approach.Research (Washington, D.C.) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A combinatorial approach was used to present primary neurons with a large library of topographical features in the form of micropatterned substrate for high-throughput screening of physical neural-guidance cues that can effectively promote different aspects of neuronal development, including axon and dendritic outgrowth. Notably, the neuronal-guidance capability of specific features was automatically identified using a customized image processing software, thus significantly increasing the screening throughput with minimal subjective bias. Our results indicate that the anisotropic topographies promote axonal and in some cases dendritic extension relative to the isotropic topographies, while dendritic branching showed preference to plain substrates over the microscale features. The results from this work can be readily applied towards engineering novel biomaterials with precise surface topography that can serve as guidance conduits for neuro-regenerative applications. This novel topographical screening strategy combined with the automated processing capability can also be used for high-throughput screening of chemical or genetic regulatory factors in primary neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.