SynthesisInternational journal of clinical practice2015
Healthcare provider targeted interventions to improve medication adherence: systematic review and meta-analysis.
Synthesis in International journal of clinical practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 8 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Pooled it
- Effectiveness of interventions to improve medication adherence in adults with depressive disorders: a meta-analysis.BMC psychiatry · 2022Pooled it
- Identifying Brief Message Content for Interventions Delivered via Mobile Devices to Improve Medication Adherence in People With Type 2 Diabetes Mellitus: A Rapid Systematic Review.Journal of medical Internet research · 2019Pooled it
- What are the implications for practice that arise from studies of medication taking? A systematic review of qualitative research.PloS one · 2018Pooled it
- Medication Adherence Interventions Improve Heart Failure Mortality and Readmission Rates: Systematic Review and Meta-Analysis of Controlled Trials.Journal of the American Heart Association · 2016Pooled it
- Meta-analyses of Theory Use in Medication Adherence Intervention Research.American journal of health behavior · 2016Pooled it
- Systematic Review of Clinical Practice Guidelines for the Improvement of Medication Adherence.International journal of behavioral medicine · 2015Pooled it
- Patient-Centered Outcomes of Medication Adherence Interventions: Systematic Review and Meta-Analysis.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes ResearchPooled it
- Autonomy-Supportive Healthcare, Medication Adherence, and Life Satisfaction in Adolescents with Epilepsy: A Cross-Sectional Association.Behavioral sciences (Basel, Switzerland) · 2026Article
- Healthcare provider interventions to support medication adherence: state-of-the-science overview.Frontiers in pharmacology · 2025Review
- Interventions for increasing medication adherence in heart failure patients: A narrative review.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2024Review
- Nirmatrelvir/Ritonavir Utilization for the Treatment of Non-hospitalized Adults with COVID-19 in the National Veterans Affairs (VA) Healthcare System.Infectious diseases and therapy · 2024Article
- Developing a medication adherence technologies repository: proposed structure and protocol for an online real-time Delphi study.BMJ open · 2022Article
- Healthcare professionals' perceptions on barriers and facilitators to DMARD use in rheumatoid arthritis.BMC health services research · 2022Article
- Estimating proportion of days covered (PDC) using real-world online medicine suppliers' datasets.Journal of pharmaceutical policy and practice · 2021Article
- Treatment Adherence in Integrative Medicine-Part One: Review of Literature.Integrative medicine (Encinitas, Calif.) · 2021Review
- Effect of an Alternative Newborn Naming Strategy on Wrong-Patient Errors: A Quasi-Experimental Study.Applied clinical informatics · 2020Article
- The Evidence-Based Development of an Intervention to Improve Clinical Health Literacy Practice.International journal of environmental research and public health · 2020Review
- "You Want to Give the Best Care Possible, and You Know When They Leave Your Pharmacy, You Didn't Give the Best Care Possible Most of the Time": Pharmacist- and Community Health Worker-Identified Barriers and Facilitators to Medication Adherence in Marshallese Patients.Journal of racial and ethnic health disparities · 2019Article
- Experiences and expectations of patients living with HIV on their engagement with care in Western Kenya.Patient preference and adherence · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis systematic review applied meta-analytic procedures to synthesise medication adherence (also termed compliance) interventions that focus on healthcare providers.
designComprehensive searching located studies testing interventions that targeted healthcare providers and reported patient medication adherence behaviour outcomes. Search strategies included 13 computerised databases, hand searches of 57 journals, and both author and ancestry searches. Study sample, intervention characteristics, design and outcomes were reliably coded. Standardised mean difference effect sizes were calculated using random-effects models. Heterogeneity was examined with Q and I(2) statistics. Exploratory moderator analyses used meta-analytic analogue of ANOVA and regression.
resultsCodable data were extracted from 218 reports of 151,182 subjects. The mean difference effect size was 0.233. Effect sizes for individual interventions varied from 0.088 to 0.301. Interventions were more effective when they included multiple strategies. Risk of bias assessment documented larger effect sizes in studies with larger samples, studies that used true control groups (as compared with attention control), and studies without intention-to-treat analyses.
conclusionOverall, this meta-analysis documented that interventions targeted to healthcare providers significantly improved patient medication adherence. The modest overall effect size suggests that interventions addressing multiple levels of influence on medication adherence may be necessary to achieve therapeutic outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.