Evidence map›Paper›PMID 25728083›Full record

Observational studyJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2015

Epidemiologic, clinical, and virologic characteristics of human rhinovirus infection among otherwise healthy children and adults: rhinovirus among adults and children.

Wei-Ju Chen, John C Arnold, Mary P Fairchok, Patrick J Danaher, Erin A McDonough, Patrick J Blair, Josefina Garcia, Eric S Halsey, Christina Schofield, Martin Ottolini and 4 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Wei-Ju ChenInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
John C ArnoldNaval Medical Center, San Diego, CA, USA.
Mary P FairchokInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Madigan Army Medical Center, Tacoma, WA, USA.
Patrick J DanaherDefense Institute for Medical Operations, San Antonio, TX, USA.
Erin A McDonoughNaval Health Research Center, San Diego, CA, USA.
Patrick J BlairNaval Health Research Center, San Diego, CA, USA.
Josefina GarciaNaval Medical Research Unit No. 6, Lima, Peru.
Eric S HalseyNaval Medical Research Unit No. 6, Lima, Peru.
Christina SchofieldMadigan Army Medical Center, Tacoma, WA, USA.
Martin OttoliniOffice of Curriculum, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Deepika MorInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Michelande RidoréInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Timothy H BurgessWalter Reed National Military Medical Center, Bethesda, MD, USA.
Eugene V MillarInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. Electronic address: emillar@idcrp.org.
Uniformed Services University of the Health Sciences · USNaval Health Research Center · USNaval Medical Research Unit Six · PEMadigan Army Medical Center · USNaval Medical Center San Diego · USWalter Reed National Military Medical Center · US

Funding

DATA CENTER FOR EPIDEMIOLOGIC INVESTIGATIONS OF HIVN01AI005072 · NIAID · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MCKINLAY, SONJA M · 1990 to 1994
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NIAID NIH HHS Y01 AI005072NIAID NIH HHS Y1-AI-5072
6 · The paper itself

Abstract

backgroundhuman rhinovirus (HRV) is a major cause of influenza-like illness (ILI) in adults and children. Differences in disease severity by HRV species have been described among hospitalized patients with underlying illness. Less is known about the clinical and virologic characteristics of HRV infection among otherwise healthy populations, particularly adults.

objectivesto characterize molecular epidemiology of HRV and association between HRV species and clinical presentation and viral shedding. STUDY

designobservational, prospective, facility-based study of ILI was conducted from February 2010 to April 2012. Collection of nasopharyngeal specimens, patient symptoms, and clinical information occurred on days 0, 3, 7, and 28. Patients recorded symptom severity daily for the first 7 days of illness in a symptom diary. HRV was identified by RT-PCR and genotyped for species determination. Cases who were co-infected with other viral respiratory pathogens were excluded from the analysis. We evaluated the associations between HRV species, clinical severity, and patterns of viral shedding.

resultseighty-four HRV cases were identified and their isolates genotyped. Of these, 62 (74%) were >18 years. Fifty-four were HRV-A, 11HRV-B, and 19HRV-C. HRV-C infection was more common among children than adults (59% vs. 10%, P<0.001). Among adults, HRV-A was associated with higher severity of upper respiratory symptoms compared to HRV-B (P=0.02), but no such association was found in children. In addition, adults shed HRV-A significantly longer than HRV-C (P trend=0.01).

conclusionsamong otherwise healthy adults with HRV infection, we observed species-specific differences in respiratory symptom severity and duration of viral shedding.

Indexed as

AdolescentAdultAgedChildChild, PreschoolFemaleGenotypeHumansInfantInfant, NewbornMaleMiddle AgedMolecular EpidemiologyPhylogenyPicornaviridae InfectionsProspective StudiesHRV genotypesMilitaryRhinovirusViral shedding

Identifiers

PMID25728083
PMCPMC4347877
OpenAlexW2085125153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.