ArticleStem cells (Dayton, Ohio)2015
TAF4b is required for mouse spermatogonial stem cell development.
Article in Stem cells (Dayton, Ohio), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Genetic and epigenetic insights into non-obstructive azoospermia: mechanisms, biomarkers, and clinical perspectives.Reproductive biology and endocrinology : RB&E · 2025Review
- Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia.Biology direct · 2024Article
- EEF1B2 regulates the proliferation and apoptosis of human spermatogonial stem cell lines through TAF4B.Heliyon · 2024Article
- Article
- Review
- Cell type-specific role of CBX2 and its disordered region in spermatogenesis.Genes & development · 2023Article
- Single-cell transcriptome analysis and in vitro differentiation of testicular cells reveal novel insights into male sterility of the interspecific hybrid cattle-yak.BMC genomics · 2023Article
- Sertoli cell-only syndrome: advances, challenges, and perspectives in genetics and mechanisms.Cellular and molecular life sciences : CMLS · 2023Review
- Transcription and chromatin regulation by TAF4b during cellular quiescence of developing prospermatogonia.Frontiers in cell and developmental biology · 2023Article
- TAF4b transcription networks regulating early oocyte differentiation.Development (Cambridge, England) · 2022Article
- RNA-binding protein ELAVL2 plays post-transcriptional roles in the regulation of spermatogonia proliferation and apoptosis.Cell proliferation · 2021Article
- Targeted disruption of galectin 3 in mice delays the first wave of spermatogenesis and increases germ cell apoptosis.Cellular and molecular life sciences : CMLS · 2021Article
- Screening of Integrin Heterodimers Expressed Functionally on the Undifferentiated Spermatogonial Stem Cells in the Outbred ICR Mice.International journal of stem cells · 2020Article
- Analysis of TATA-box binding protein associated factor 4b gene mutations in a Chinese population with nonobstructive azoospermia.Medicine · 2020Observational
- FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation.Nucleic acids research · 2020Article
- ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis.Molecular and cellular biology · 2020Article
- Dynamic and regulated TAF gene expression during mouse embryonic germ cell development.PLoS genetics · 2020Article
- The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling.Stem cell reports · 2019Article
- DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.Cell reports · 2018Article
- Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat.Andrology · 2017Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Long-term mammalian spermatogenesis requires proper development of spermatogonial stem cells (SSCs) that replenish the testis with germ cell progenitors during adult life. TAF4b is a gonadal-enriched component of the general transcription factor complex, TFIID, which is required for the maintenance of spermatogenesis in the mouse. Successful germ cell transplantation assays into adult TAF4b-deficient host testes suggested that TAF4b performs an essential germ cell autonomous function in SSC establishment and/or maintenance. To elucidate the SSC function of TAF4b, we characterized the initial gonocyte pool and rounds of spermatogenic differentiation in the context of the Taf4b-deficient mouse testis. Here, we demonstrate a significant reduction in the late embryonic gonocyte pool and a deficient expansion of this pool soon after birth. Resulting from this reduction of germ cell progenitors is a developmental delay in meiosis initiation, as compared to age-matched controls. While GFRα1+ spermatogonia are appropriately present as Asingle and Apaired in wild-type testes, TAF4b-deficient testes display an increased proportion of long and clustered chains of GFRα1+ cells. In the absence of TAF4b, seminiferous tubules in the adult testis either lack germ cells altogether or are found to have missing generations of spermatogenic progenitor cells. Together these data indicate that TAF4b-deficient spermatogenic progenitor cells display a tendency for differentiation at the expense of self-renewal and a renewing pool of SSCs fail to establish during the critical window of SSC development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.