ArticleHuman brain mapping2015
Measuring vascular reactivity with breath-holds after stroke: a method to aid interpretation of group-level BOLD signal changes in longitudinal fMRI studies.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Multi-echo BOLD fMRI improves cerebrovascular reactivity estimates in stroke.bioRxiv : the preprint server for biology · 2026Article
- Iterative delay correction improves breath-hold cerebrovascular reactivity mapping in clinical populations.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Predicting Breath Hold Task Compliance From Head Motion.Journal of magnetic resonance imaging : JMRI · 2026Article
- MRI mapping of hemodynamics in the human spinal cord.Scientific reports · 2025Article
- Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI.Experimental physiology · 2025Review
- Cerebrovascular reactivity and response times describe recent ischaemic symptomatology in patients with moyamoya.Brain communications · 2025Article
- Sex-specific cerebrovascular reactivity differences in autistic children related to functional connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Improved cerebrovascular reactivity mapping using coherence weighted general linear model in the frequency domain.NeuroImage · 2023Article
- IC3 protocol: a longitudinal observational study of cognition after stroke using novel digital health technology.BMJ open · 2023Article
- Hemodynamic timing in resting-state and breathing-task BOLD fMRI.NeuroImage · 2023Article
- Comparing end-tidal CONeuroImage · 2023Article
- Article
- Agreement in cerebrovascular reactivity assessed with diffuse correlation spectroscopy across experimental paradigms improves with short separation regression.Neurophotonics · 2023Article
- Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution.Frontiers in neuroimaging · 2023Article
- Understanding recovery of language after stroke: insights from neurovascular MRI studies.Frontiers in language sciences · 2023Article
- Cerebrovascular Reactivity Mapping Using Resting-State Functional MRI in Patients With Gliomas.Journal of magnetic resonance imaging : JMRI · 2022Article
- Optical imaging and spectroscopy for the study of the human brain: status report.Neurophotonics · 2022Article
- Hemodynamic evaluation of patients with Moyamoya Angiopathy: comparison of resting-state fMRI to breath-hold fMRI and [Neuroradiology · 2022Article
- CVR-MRICloud: An online processing tool for CO2-inhalation and resting-state cerebrovascular reactivity (CVR) MRI data.PloS one · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Blood oxygenation level-dependent (BOLD) contrast functional magnetic resonance imaging (fMRI) is a widely used technique to map brain function, and to monitor its recovery after stroke. Since stroke has a vascular etiology, the neurovascular coupling between cerebral blood flow and neural activity may be altered, resulting in uncertainties when interpreting longitudinal BOLD signal changes. The purpose of this study was to demonstrate the feasibility of using a recently validated breath-hold task in patients with stroke, both to assess group level changes in cerebrovascular reactivity (CVR) and to determine if alterations in regional CVR over time will adversely affect interpretation of task-related BOLD signal changes. Three methods of analyzing the breath-hold data were evaluated. The CVR measures were compared over healthy tissue, infarcted tissue and the peri-infarct tissue, both sub-acutely (∼2 weeks) and chronically (∼4 months). In this cohort, a lack of CVR differences in healthy tissue between the patients and controls indicates that any group level BOLD signal change observed in these regions over time is unlikely to be related to vascular alterations. CVR was reduced in the peri-infarct tissue but remained unchanged over time. Therefore, although a lack of activation in this region compared with the controls may be confounded by a reduced CVR, longitudinal group-level BOLD changes may be more confidently attributed to neural activity changes in this cohort. By including this breath-hold-based CVR assessment protocol in future studies of stroke recovery, researchers can be more assured that longitudinal changes in BOLD signal reflect true alterations in neural activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.