Evidence map›Paper›PMID 25727508›Full record

ReviewSeminars in pediatric neurology2014

Status epilepticus and refractory status epilepticus management.

Nicholas S Abend, David Bearden, Ingo Helbig, Jennifer McGuire, Sona Narula, Jessica A Panzer, Alexis Topjian, Dennis J Dlugos

Abstract readReview
In one paragraph

Review in Seminars in pediatric neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Treatment of Established Status Epilepticus.Journal of clinical medicine · 2016
    Review
  13. Management of Status Epilepticus in Children.Journal of clinical medicine · 2016
    Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nicholas S AbendDepartment of Neurology, The Children׳s Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Children׳s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address: abend@email.chop.edu.
David BeardenDepartment of Neurology, The Children׳s Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Children׳s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Ingo HelbigDepartment of Neurology, The Children׳s Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Children׳s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Jennifer McGuireDepartment of Neurology, The Children׳s Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Children׳s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Sona NarulaDepartment of Neurology, The Children׳s Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Children׳s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Jessica A PanzerDepartment of Neurology, The Children׳s Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Children׳s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Alexis TopjianDepartment of Anesthesia and Critical Care Medicine, The Children׳s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Dennis J DlugosDepartment of Neurology, The Children׳s Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Children׳s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Impact of Initial Therapy and Response on Long Term Outcome in Children with CAEU01NS045911 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI GLAUSER, TRACY A · 2003 to 2013
$31.1M
The Epilepsy Phenome/ Genome Project (EPGP)U01NS053998 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWENSTEIN, DANIEL H · 2007 to 2013
$26.4M
Training Program in Neurodevelopmental DisabilitiesT32NS007413 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI AMELIA J EISCH, ERIC D MARSH · 1998 to 2026
$8.9M
Neurologic Clinical Epidemiology Training ProgramT32NS061779 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Andrea Lauren Christman Schneider, Allison Willis · 2008 to 2026
$4.6M
NSADA Training Grant for Child NeurologistsK12NS049453 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI TENNEKOON, GIHAN I · 2006 to 2015
$4.4M
2 of 7 EPI4K - Phenotyping Clinical Informatics Core U01NS077276 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWENSTEIN, DANIEL H · 2011 to 2015
$3.1M
Multi-Institutional Pediatric Epilepsy Decision SupportR01LM011124 · NLM · CINCINNATI CHILDRENS HOSP MED CTR · PI PESTIAN, JOHN P · 2011 to 2013
$955k
Non-convulsive seizures in critically ill children:physiology and outcomeK23NS076550 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ABEND, NICHOLAS SCOTT · 2011 to 2015
$877k
Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac ArrestK23NS075363 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI TOPJIAN, ALEXIS A. · 2012 to 2016
$874k
NINDS NIH HHS 1R01NS053998NINDS NIH HHS 2U01NS045911NINDS NIH HHS K12 NS049453NINDS NIH HHS K12-NS049453NINDS NIH HHS K23 NS075363NINDS NIH HHS K23-NS075363NINDS NIH HHS K23 NS076550NINDS NIH HHS K23-NS076550NINDS NIH HHS T32 NS007413NINDS NIH HHS T32 NS061779NINDS NIH HHS U01 NS045911NINDS NIH HHS U01 NS053998NINDS NIH HHS U01 NS077276NINDS NIH HHS U01NS077276NLM NIH HHS 1R01LM011124NLM NIH HHS R01 LM011124
6 · The paper itself

Abstract

Status epilepticus (SE) describes persistent or recurring seizures without a return to baseline mental status and is a common neurologic emergency. SE can occur in the context of epilepsy or may be symptomatic of a wide range of underlying etiologies. The clinician's aim is to rapidly institute care that simultaneously stabilizes the patient medically, identifies and manages any precipitant conditions, and terminates seizures. Seizure management involves "emergent" treatment with benzodiazepines followed by "urgent" therapy with other antiseizure medications. If seizures persist, then refractory SE is diagnosed and management options include additional antiseizure medications or infusions of midazolam or pentobarbital. This article reviews the management of pediatric SE and refractory SE.

Indexed as

AnticonvulsantsChildHumansStatus EpilepticusAnticonvulsants

Identifiers

PMID25727508
PMCPMC4346709
OpenAlexW2032410305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.